UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UCSF researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
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University of California San Francisco
Give to UCSFRaising hopes for cell-based therapies, UCSF researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
Shinya Yamanaka's Nobel Prize for stem cell research brought fresh attention to something UCSF long ago sensed and seized: the promise of regeneration medicine for repairing or replacing damaged cells, tissues, and even whole organs.
A key type of human brain cell developed in the laboratory grows seamlessly when transplanted into the brains of mice, UCSF researchers have found.
Epilepsy that does not respond to drugs can be halted in adult mice by transplanting a specific type of cell into the brain, UCSF researchers have discovered, raising hope that a similar treatment might work in severe forms of human epilepsy.
UCSF is creating a Center for Digital Health Innovation to lead the transformation of health care delivery and discovery into the era of individualized precision medicine.
New research conducted at UCSF sheds lights on how fingers and toes are formed in the womb, a finding likely to fundamentally reshape biologists' understanding of how cells communicate to each other during development.
Specific DNA once dismissed as junk plays an important role in brain development and might be involved in several devastating neurological diseases, UCSF scientists have found.
A Phase 2 clinical trial testing a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, may change the standard of care for this disease, according to UCSF doctors who led the research.
By stimulating one part of the brain with laser light, researchers at the National Institutes of Health and the Ernest Gallo Clinic and Research Center at UCSF have shown that they can wipe away addictive behavior in rats – or conversely turn non-addicted rats into compulsive cocaine seekers.
<p>An innovative project to develop a potential therapy to treat a wide range of cancers has won a major UC San Francisco award that aims to drive promising early-stage research through the complex process of translating ideas into patient benefit.</p>
<p>A UCSF team has developed an ambitious online cardiovascular study using smartphones, with the goal of enrolling 1 million people from all over the world to improve heart health.</p>
<p>A team of researchers at UCSF has uncovered the neurological basis of speech motor control, the complex coordinated activity of tiny brain regions that controls our lips, jaw, tongue and larynx as we speak.</p>
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, UCSF researchers have discovered.
Hospital MRIs may be better at predicting long-term outcomes for people with mild traumatic brain injuries than CT scans, according to a clinical trial led by researchers at UCSF and the San Francisco General Hospital and Trauma Center.
William Seeley maps the path of frontotemporal dementia through the brain, correlating specific damage with behavioral change. By studying the disease from self to circuits to cells, this visionary neurologist searches for inroads to treatment.
DNA sequences obtained from a handful of patients with multiple sclerosis at the UCSF Medical Center have revealed the existence of an “immune exchange” that allows the disease-causing cells to move in and out of the brain.
<p>UCSF neuroscientists have found that by training on attention tests, people young and old can improve brain performance and multitasking skills.</p>
<p>Researchers at UCSF have identified the lynchpin that activates brown fat cells, which burn fat molecules instead of storing them, making them the focus of pharmaceutical research aimed at fighting obesity.</p>
<p>A new study that represents a significant first step in exploring the potential of stem cells to treat neurological disease is a “natural outgrowth” of a longstanding culture of interdisciplinary collaboration in UCSF neonatology — a culture that UCSF Benioff Children's Hospital physicians David Rowitch and Donna Ferriero work hard to sustain.</p>
For the first time, a clinical trial led by UCSF investigators and sponsored by Stem Cells Inc., has shown that transplanted neural stem cells appear to produce myelin in the brains of four young children with an early-onset, fatal disease.
<p>Shinya Yamanaka, MD, PhD, a senior investigator at the Gladstone Institutes and a professor of anatomy at UCSF, has won the 2012 Nobel Prize in Physiology or Medicine for his discovery of how to transform ordinary adult skin cells into cells that are capable of developing into any cell in the human body.</p>
<p>Here are answers to frequently asked questions about induced pluripotent stem cells, or iPS cells, the type of cell that has been reprogrammed from an adult cell, such as a skin or blood cell.</p>
<p>UCSF and its affiliates have been major players in the transformation of San Francisco as a leading center of innovation in health care and biosciences, according to a new report released Wednesday.</p>
<p>A patient in rural Uganda is diagnosed with tuberculosis but never begins treatment. In Vietnam, someone with infectious TB might never be diagnosed because the health center is too far away. Adithya Cattamanchi, MD, is working to address challenges in Uganda and Vietnam by applying techniques of <a href="http://accelerate.ucsf.edu/training/ids">implementation </a><a href="http://accelerate.ucsf.edu/training/ids">science</a>.</p>
<p>Although it’s proven that contraception prevents pregnancy, it’s also clear that many women who don’t want to get pregnant don’t use or don’t have access to contraception. Christine Dehlendorf, MD, MAS, a family physician based at San Francisco General Hospital and Trauma Center, used implementation science to help women navigate this issue.</p>