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UCSF researchers have found a way to knock down cancers caused by a tumor-driving protein called “myc,” paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments.
The nation's premier pharmacy school capped its academic year by welcoming a new dean and celebrating a stellar class of graduates at its commencement ceremony on May 24.
The ability to form blood vessels is one of evolution’s crowning achievements. Now, scientists at the Gladstone Institutes have identified the molecular signals that direct the process of committing endothelial cells to become arteries or veins during embryonic development.
A new UCSF study highlights the potential importance of the vast majority of human DNA that lies outside of genes within the cell.
Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs lowered the risk of stroke by almost one-third, compared to aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks.
Aspirin is known to lower risk for some cancers, and a new UCSF-led study points to a possible explanation, with the discovery that aspirin slows the accumulation of DNA mutations in abnormal cells in at least one pre-cancerous condition.
Pharmacologist Lisa Bero, PhD, answers our questions about industry bias in clincial trials.
New research conducted at UCSF sheds lights on how fingers and toes are formed in the womb, a finding likely to fundamentally reshape biologists' understanding of how cells communicate to each other during development.
The Li Ka Shing Foundation has pledged $2 million to support UCSF’s efforts to advance precision medicine, an emerging field aimed at revolutionizing medical research and patient care.
<p>UCSF has named a highly accomplished pharmacist and clinical scientist, B. Joseph Guglielmo, PharmD, a 34-year member of the UCSF faculty, to lead the nation’s premier School of Pharmacy.</p>
Five UCSF scientists – bioengineers Tejal Desai and Shuvo Roy, MD/PhD candidate Mozziyar Etemadi, microbiologist Joe DeRisi, and physician/surgeon Michael Harrison – trace their path toward five inventions that are changing the face of medicine.
<p>Researchers at UCSF have identified the lynchpin that activates brown fat cells, which burn fat molecules instead of storing them, making them the focus of pharmaceutical research aimed at fighting obesity.</p>
<p>UCSF and its affiliates have been major players in the transformation of San Francisco as a leading center of innovation in health care and biosciences, according to a new report released Wednesday.</p>
People with lung cancer who are treated with the drug Tarceva face a daunting uncertainty: although their tumors may initially shrink, it's not a question of whether their cancer will return—it's a question of when. And for far too many, it happens far too soon.
A new approach to drug design, pioneered by a group of researchers at UCSF and Mt. Sinai, New York, promises to help identify future drugs to fight cancer and other diseases that will be more effective and have fewer side effects.
<p>Academic medical centers can play a larger role in drug development and testing, according to an FDA official, who says there is a need for better strategies to identify winners, minimize costs and reduce failures during drug development.</p>
<p>Malaria is an infectious disease caused by a parasite transmitted from person to person by the bite of a mosquito. In the past two centuries, numerous research and public health efforts worldwide have sought to combat this ancient scourge as this timeline shows.</p>
Scientists have known for years that when vampire bats tear through an animal’s skin with their razor-sharp teeth, their noses guide them to the best spots – where a precise bite will strike a vein and spill forth nourishing blood. But nobody knew exactly how bats knew where to bite – until now.
Researchers at UCSF and in Michigan, North Carolina and Spain have discovered how genetic mutations cause a number of rare human diseases, which include Meckel syndrome, Joubert syndrome and several other disorders.
<p>Having developed an algorithm that discovered a large quantity of drug-producing bacteria in and on humans, Fischbach has turned his lab’s attention to studying their populations and interactions with each other. This, he posits, can greatly influence a person’s overall health and disease.</p>
<p>Swallowing pills means medication must face the challenge of surviving the harsh environment of the digestive tract. As a result, people must take larger doses than they need. Using micro and nano-fabrication techniques developed by the computer chip industry, Desai’s lab is creating tiny devices that take multiple drugs directly to where they are needed, using less medication, minimizing side effects and making the process safer for the patient. </p>
A 10-month study of healthy honey bees by UCSF scientists has identified four new viruses that infect bees, while revealing that each of the viruses or bacteria previously linked to colony collapse is present in healthy hives as well.
<p>Experts at UCSF and Caltech are pushing the boundaries of creative problem solving to address important clinical problems with the hope that the talent pool at both institutions, combined with an entrepreneurial spirit, will advance health care innovation.</p>
Men and women had starkly different immune system responses to chronic post-traumatic stress disorder, with men showing no response and women showing a strong response, in two studies by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.
Researchers exploring human metabolism at UCSF have uncovered a handful of chemical compounds that regulate fat storage in worms, offering a new tool for understanding obesity and finding future treatments for diseases associated with obesity.
UCSF researchers have developed a new approach to decoding the vast information embedded in an organism’s genome, while shedding light on exactly how cells interpret their genetic material to create RNA messages and launch new processes in the cell.
Weight gain and environmental pollutants might be linked, an award-winning worm researcher suggests.
A team of UCSF researchers has engineered E. coli with the key molecular circuitry that will enable genetic engineers to program cells to communicate and perform computations.