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Bacteria that normally live in and upon us have genetic blueprints that enable them to make thousands of molecules that act like drugs, and some of these molecules might serve as the basis for new human therapeutics, according to UCSF researchers.
Severe combined immunodeficiency (SCID), a potentially life-threatening, but treatable, disorder affecting infants, is twice as common as previously believed, according to a new study that is the first to examine the national impact of this newborn screening test.
UCSF researchers have identified cells’ unique features within the developing human brain, using the latest technologies for analyzing gene activity in individual cells, and have demonstrated that large-scale cell surveys can be done much more efficiently and cheaply than was previously thought possible.
A UCSF physician who treats birth defects affecting the face has teamed up with a European expert on animal evolution to create rodent teeth that harken back in evolutionary time.
The immune system ages and weakens with time, making the elderly prone to life-threatening infection and other maladies, and a UCSF research team now has discovered a reason why.
The popular idea that Northern Europeans developed light skin to absorb more UV light so they could make more vitamin D – vital for healthy bones and immune function – is questioned by UC San Francisco researchers in a new study.
In the most comprehensive study of the Mexican population to date, researchers from UCSF and Stanford University, along with Mexico’s National Institute of Genomic Medicine, have identified tremendous genetic diversity.
A team of researchers studying a flowering plant has zeroed in on the way cells manage external signals to adapt to prevailing conditions, a capability that is essential for cells to survive in a fluctuating environment.
Joshua Osborn was fighting for his life against a mysterious ailment. With his options dwindling, a team at UCSF employed advanced DNA sequencing technology to track down the culprit.
New genomic research led by UCSF scientists reveals that two common gene variants that lead to longer telomeres also significantly increase the risk of developing the deadly brain cancers known as gliomas.
A 14-year-old boy’s turnaround and quick recovery after mysteriously being stricken by brain-inflaming encephalitis shows that the newest generation of DNA analysis tools can be harnessed to reveal the cause of a life-threatening infection even when physicians have no suspects.
From prostate cancer to immunotherapy to genetic testing, UCSF research is providing new insights and aiding in the development of new treatment strategies for cancer.
A scientific team led by the Gladstone Institutes and UCSF has discovered that a common form of a gene already associated with long life also improves learning and memory.
Nobel Prize winner Stanley Prusiner is closing in on better treatments for Alzheimer's, Parkinson's and other brain diseases, and an unlikely new partnership will get him there faster.
Four UCSF-affiliated researchers are among 102 recipients of the Presidential Early Career Awards for Scientists and Engineers.
Genetic testing can help doctors choose the most effective and economical drugs to prevent blood clots in the half a million patients in the U.S. who receive coronary stents each year, according to a new study led by a UCSF researcher.
Scientists at the UCSF-affiliated Gladstone Institutes have found a way to efficiently edit the human genome one letter at a time, paving the way for therapies that cure disease.
Geneticists from Ohio, California and Japan used stem cells to correct a defective “ring chromosome” with a normal chromosome. Such therapy has the promise to correct chromosome abnormalities that give rise to birth defects, mental disabilities and growth limitations.
UCSF and Quest Diagnostics, the world's leading provider of diagnostic information services, have formed a collaboration to accelerate the translation of biomedical research into advanced diagnostics in the field of precision medicine.
UCSF has launched a new specialty in Clinical Informatics, addressing the growing need to harness the power of massive quantities of patient data in the era of precision medicine and health care reform.
Experts across UCSF weigh in on what some of 2014's top trends are in research and patient care.
Research led by scientists at the UCSF-affiliated Gladstone Institutes has identified the precise chain of molecular events in the human body that drives the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS. Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells.
A team led by scientists from UCSF has discovered that recurrent gliomas may have genetic profiles that are markedly different from those of the initial tumors that spawned them.
Scientists at the UCSF-affiliated Gladstone Institutes have devised a new molecular sensor that can detect MS at its earliest stages, even before the onset of physical signs.
Top thinkers gather at UCSF to help make the new field a reality.
Pamela Munster, MD, is program leader of Developmental Therapeutics at UCSF’s Helen Diller Family Comprehensive Cancer Center. She shares a breast cancer story here – her own.
UCSF is one of the first pharmacy schools in the nation to offer its students genetic testing for drug response. It’s just one way they're learning about the potential of precision medicine.
A team led by UCSF scientists has identified the disruption of a single type of cell – in a particular brain region and at a particular time in brain development – as a significant factor in the emergence of autism.
Precision Medicine Pillar No. 6: Digital Health. The Center for Digital Health Innovation shepherds the development of digital health innovations created at UCSF and validates the effectiveness of devices from both inside and outside the institution.
Precision Medicine Pillar No. 5: Omics Medicine. Molecular biologist Nevan Krogan's work is not only illuminating how genes and proteins function, it's also shedding light on the underlying biology of disease for each person.
