Archive: Newborn Gut Microbiome Predicts Later Allergy and Asthma, Study Finds
Gut microbes present in some one-month-old infants predict a three-fold higher risk of developing allergic reactions by age two and asthma by age four.
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Archive: Immune-Cell Population Predicts Immunotherapy Response in Melanoma
The abundance of a subtype of white blood cells in melanoma tumors can predict whether or not patients will respond to a form of cancer immunotherapy known as checkpoint blockade, according to a new study led by UCSF researchers and physicians.
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Archive: Gut Bacteria Linked to Rare Autoimmune Disease
A new study led by UCSF scientists shows that a bacterium commonly found in the human gut is overrepresented in patients with a rare, often disabling autoimmune disease known as neuromyelitis optica.
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Archive: Researchers Map Zika’s Routes to the Developing Fetus
Zika virus can infect numerous cell types in the human placenta and amniotic sac, according to researchers at UCSF and UC Berkeley who show in a new paper how the virus travels from a pregnant woman to her fetus.
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Archive: Go-Between Immune Cell is Key to Priming the Body’s Fight Against Cancer
Using advanced imaging technology that allowed them to spy on interactions among cells in the lymph nodes of living mice, a research team led by UCSF scientists has identified a cell that is a key player in mounting the immune system’s defense against cancer.
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Archive: Covert Inflammation May Trigger Many Forms of Cancer
A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don’t display typical signs of inflammation.
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Archive: UCSF Researchers Reappraise Treatment for Belly Birth Defect
UC San Francisco researchers have shed light on how the immune system of a fetus can run amok, triggering inflammation in the developing intestines that protrude outside of the body through a hole beside the belly button.
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Wrapping Up Multiple Sclerosis
With one drug to shut down its progression and another to undo its damage, plus a worldwide effort stalking the origins of multiple sclerosis, MS doesn’t stand a chance.
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Archive: UCSF Immunologist to Head New Parker Institute for Cancer Immunotherapy
Renowned UCSF immunologist Jeffrey Bluestone, PhD, has been named president and CEO of the Parker Institute for Cancer Immunotherapy, a national initiative launched with a $250 million grant from The Parker Foundation, established by Silicon Valley entrepreneur Sean Parker.
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Archive: UCSF Research Suggests New Model for Cancer Metastasis
Scientists at UC San Francisco have been able to directly observe, for the first time, how invasive cancer cells create a beachhead as they migrate to the lung in a mouse model of metastatic cancer.
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Archive: Saturated Fat ‘Short-Circuits’ Immune Cells To Trigger Inflammation
Research by UCSF scientists has opened up a surprising new avenue for potential therapies to reduce the risk of type 2 diabetes and other metabolic disorders that are associated with chronic tissue inflammation in obesity.
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Archive: ‘Unhealthy’ Microbiomes Could Promote Metabolic Disease
Leading microbiome researchers recently came to UCSF to share the newest insights about how improving our relationship with our bodies’ microbial ecosystems could be the next big breakthrough in treating metabolic disease.
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Archive: Tricked-Out Immune Cells Could Attack Cancer, Spare Healthy Cells
UCSF scientists have created a new class of highly customizable biological sensors that can be used to form “logic gates” inside cells of the immune system, giving these cells the capability to home in on and kill a wide range of cancer cells while preventing them from attacking normal tissue.
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Archive: Myelin Cells Swing Along Blood Vessels to Traverse the Brain
The cells that create myelin, a fatty material that insulates nerve fibers in the brain’s white matter, migrate into the developing brain by climbing and swinging on blood vessels, according to new research led by UCSF scientists.
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Archive: $20M Grant from amfAR Funds Institute for HIV Cure Research
In a bid to end the worst epidemic in modern times, the Foundation for AIDS Research (amfAR) is funding an ambitious effort based in San Francisco to eliminate the human immunodeficiency virus (HIV) from those who are infected.
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Archive: Immunotherapy For Type 1 Diabetes Deemed Safe In First U.S. Trial
In the first U.S. safety trial of a new form of immunotherapy for type 1 diabetes, patients experienced no serious adverse reactions after receiving infusions of as many as 2.6 billion cells that had been specially selected to protect the body’s ability to produce insulin.
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Archive: Skin Must Develop Tolerance to ‘Good’ Bacteria Early In Life, Says New Study
A wave of specialized immune cells entering the skin in early life may induce tolerance to the hundreds of species of so-called friendly bacteria that live on the surface of the body.
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Archive: New Sean N. Parker Autoimmune Research Laboratory is Launched at UCSF
A $10 million gift from The Parker Foundation, founded by Silicon Valley entrepreneur and philanthropist Sean Parker, will establish a new research laboratory within the UCSF Diabetes Center devoted to understanding autoimmunity.
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Archive: Doctors Call on Hospitals to Oppose the Overuse Of Antibiotics in Animal Agriculture
To help stop the spread of antibiotic resistance, UCSF scientists are urging hospitals around the country to stop buying meat from animals that were given antibiotics for growth promotion.
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Archive: 3 Ways Viruses Have Changed Science for the Better
A virus is nature’s efficient little killer. They’re really good at what they do, and we’ve been able to harness their skills to learn about – and potentially improve – human health in several ways.
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Archive: ‘Remote Control’ of Immune Cells Opens Door to Safer, More Precise Cancer Therapies
UCSF researchers have engineered a molecular “on switch” that allows tight control over the actions of T cells, immune system cells that have shown great potential as therapies for cancer.
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Archive: Rare Melanoma Carries Unprecedented Burden of Mutations
A rare, deadly form of skin cancer known as desmoplasmic melanoma may possess the highest burden of gene mutations of any cancer, suggesting that immunotherapy may be a promising approach for treatment, according to an international team led by UCSF scientists.
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Archive: Short Sleepers Are Four Times More Likely to Catch a Cold
A new study led by a UCSF sleep researcher supports what parents have been saying for centuries: to avoid getting sick, be sure to get enough sleep.
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Archive: Mammary Gland Is Shaped by Adaptive Immune System During Development
UCSF researchers have discovered that the adaptive immune system plays an active role in guiding the normal development of mammary glands, the only organs that develop predominantly after birth, beginning at puberty.
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Archive: California Initiative to Advance Precision Medicine Announces Funding for 2 Projects
Two demonstration projects that aim to yield quick results for patients have been selected by the new California Initiative to Advance Precision Medicine, a public-private effort launched by Governor Edmund G. Brown Jr.
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Archive: In CRISPR Advance, Scientists Successfully Edit Human T Cells
In a project spearheaded by investigators at UCSF, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
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Archive: Age-Related Cognitive Decline Tied to Immune-System Molecule
A blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline, suggests a new study.
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Archive: Scientists Identify Progenitor Cells for Blood and Immune System
UC San Francisco scientists have identified characteristics of a family of daughter cells, called MPPs, which are the first to arise from stem cells within bone marrow that generate the entire blood system.
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Archive: Microclinics Help Keep Kenyan HIV Patients in Care
A team led by researchers from UCSF, Organic Health Response and Microclinic International is reporting results of a study that showed significant benefits of microclinics – an innovative intervention that mobilized rural Kenyan HIV patients’ informal social networks to support their staying in care.
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Archive: UCSF-Led Study Explains How Early Childhood Vaccination Reduces Leukemia Risk
A team led by UCSF researchers has discovered how a commonly administered vaccine protects against acute lymphoblastic leukemia, the most common type of childhood cancer.