Archive: Big Ideas in Health and Science for 2016
We asked experts across UCSF to identify what's ahead in how we approach research, what disease areas will see major advances, and where basic science will be translating into real treatments.
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Archive: ‘Purity’ Of Tumor Samples May Significantly Bias Genomic Analyses
A new study by UCSF scientists shows that the proportion of normal cells, especially immune cells, intermixed with cancerous cells in a given tissue sample may significantly skew the results of genetic analyses and other tests performed both by researchers and by physicians selecting precision therapies.
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Archive: Sensory Illusion Causes Cells to Self-Destruct
UCSF researchers has discovered that single-celled yeast have sensory biases that can be hacked by a carefully engineered illusion, a finding that could be used to develop new approaches to fighting diseases such as cancer.
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Archive: Working Up A Sweat May Protect Men From Lethal Prostate Cancer
A study that tracked tens of thousands of midlife and older men for more than 20 years has found that vigorous exercise and other healthy lifestyle habits may cut their chances of developing a lethal type of prostate cancer by up to 68 percent.
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Archive: Human Gene Prevents Regeneration in Zebrafish
UCSF researchers have found a human gene that could one day allow physicians to correct congenital deformities, regrow damaged fingers, or even mend a broken heart.
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Archive: Melanoma’s Genetic Trajectories Are Charted in New Study
An international team of scientists led by UCSF researchers has mapped out the genetic trajectories taken by melanoma as it evolves from early skin lesions, known as precursors, to malignant skin cancer.
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Archive: UCSF and GSK Launch New Collaborative Research Model
UCSF has launched a collaboration with international pharmaceutical company GlaxoSmithKline plc (GSK) to promote early-stage research with the potential to translate into new therapies for cancer, obesity and antibiotic resistant bacteria.
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Archive: Rare Childhood Leukemia Reveals Surprising Genetic Secrets
A coalition of leukemia researchers led by scientists from UCSF has discovered surprising genetic diversity in juvenile myelomonocytic leukemia (JMML), a rare but aggressive childhood blood cancer.
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Archive: Online Advertising Can Deliver Targeted Cancer Prevention Messages, UCSF Study Finds
Online advertising based on Google search terms is a potentially effective way to deliver targeted cancer prevention education, according to a study led by Eleni Linos, MD, DrPH, assistant professor of dermatology at UCSF.
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Archive: Gay and Bisexual Men Report Higher Rates of Both Indoor Tanning and Skin Cancer Than Heterosexual Men
Gay and bisexual men were up to six times more likely than heterosexual men to take part in indoor tanning, and twice as likely to report a history of skin cancer, according to a study led by UCSF researchers.
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Archive: These Researchers Targeted Would-Be Tanners With Google Ads About Skin Cancer
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Archive: Younger Adults, Teens Cured of Cancer Face Higher Odds for New Malignancy
Adolescents and adults under 40 who have been successfully treated for cancer are at heightened risk of developing a second unrelated cancer, on average 15 years later, according to a study.
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Archive: ‘Remote Control’ of Immune Cells Opens Door to Safer, More Precise Cancer Therapies
UCSF researchers have engineered a molecular “on switch” that allows tight control over the actions of T cells, immune system cells that have shown great potential as therapies for cancer.
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Archive: Metastatic Breast Cancer Cells Turn On Stem Cell Genes
UCSF scientists describe capturing and studying individual metastatic cells from human breast cancer tumors implanted into mice as the cells escaped into the blood stream and began to form tumors elsewhere in the body.
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Archive: Building Human Breast Tissue, Cell by Cell
Zev Gartner is working to building a fully functioning 3-D human breast tissue that will allow him to test potential cancer therapies, an innovation that's earned him a spot among Popular Science's "Brilliant 10" this year.
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Archive: Antibody Network Partners With Celgene for Cancer Therapies
A new collaboration between Celgene Corp. and the Recombinant Antibody Network (RAN), a consortium comprising research groups from UCSF, the University of Chicago and the University of Toronto, will support the development of next-generation, antibody-based cancer therapies.
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Archive: Crunching Numbers to Combat Cancer
UCSF has received a National Cancer Institute grant of $5 million over the next five years to lead a massive effort to integrate the data from all experimental models across all types of cancer.
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Archive: Childhood Cancer Research at UCSF to Transcend Tissue Types With Innovative Grant
Researchers at UCSF are leading a five-year, $10 million research project dedicated to pediatric cancer, funded by the first grant of its kind to focus on a molecular pathway that underlies many cancers.
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Archive: Rare Melanoma Carries Unprecedented Burden of Mutations
A rare, deadly form of skin cancer known as desmoplasmic melanoma may possess the highest burden of gene mutations of any cancer, suggesting that immunotherapy may be a promising approach for treatment, according to an international team led by UCSF scientists.
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Archive: Genetic Makeup May Make Radiation Riskier for Pediatric Cancer Patients
Genetic vulnerabilities associated with childhood cancers may make children undergoing radiation therapy more susceptible than adults to secondary cancers, according to novel insights from researchers at UCSF.
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Archive: Drug for Fungal Infections in Lung Transplant Recipients Increases Risk for Skin Cancer, Even Death
Voriconazole, a prescription drug commonly used to treat fungal infections in lung transplant recipients, significantly increases the risk for skin cancer and even death, according to a new study by UCSF researchers.
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Archive: DNA-Guided 3-D Printing of Human Tissue is Unveiled
A UCSF-led team has developed a technique to build tiny models of human tissues, called organoids, more precisely than ever before using a process that turns human cells into a biological equivalent of LEGO bricks.
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Archive: Mammary Gland Is Shaped by Adaptive Immune System During Development
UCSF researchers have discovered that the adaptive immune system plays an active role in guiding the normal development of mammary glands, the only organs that develop predominantly after birth, beginning at puberty.
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Archive: Survivors of Childhood Cancer Have High-Risk of Recurrent Stroke
A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.
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Archive: Tool Boosts Accuracy in Assessing Breast Cancer Risk
A national risk model that gauges a woman’s chance of developing breast cancer has been refined to give a more accurate assessment.
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Archive: Common Class of ‘Channel Blocking’ Drugs May Find a Role in Cancer Therapy
Ion channel blockers, commonly used to treat cardiac, neurological and psychiatric disorders, might prove useful in cancer therapy, according to research findings in fruit flies and mice by UCSF scientists.
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Archive: For Prostate Cancer Patients, Risk-Specific Therapies Now More the Norm
After decades of overtreatment for low-risk prostate cancer and inadequate management of its more aggressive forms, patients are now more likely to receive medical care matched to level of risk, according to a UCSF study.
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Archive: As Smoking Declines, More Are Likely to Quit
A UCSF study shows that as smoking has declined, continuing smokers have smoked less and are more likely to try to quit.
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Archive: Scientists Identify Progenitor Cells for Blood and Immune System
UC San Francisco scientists have identified characteristics of a family of daughter cells, called MPPs, which are the first to arise from stem cells within bone marrow that generate the entire blood system.
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Archive: Cancer Blocked by Halving Levels of Protein Thought To Be ‘Untouchable’
A team of UC San Francisco and Stanford University scientists has discovered that a protein thought to be crucial for the body to develop and function correctly can be reduced by half in mice with no apparent ill effects.