Researchers Develop Stem Cell Therapies for Acute Lung Injury
A team of UCSF researchers developing cell-based therapies for acute respiratory distress syndrome benefited from advisors who helped identify gaps in their development plan.
University of California San Francisco
Give to UCSFA team of UCSF researchers developing cell-based therapies for acute respiratory distress syndrome benefited from advisors who helped identify gaps in their development plan.
Stem-cell researchers at UCSF have found a key role for a protein called BMI1 that may help scientists direct the development of tissues to replace damaged organs in the human body.
A UCSF-led team has discovered that vitamin C affects whether genes are switched on or off inside mouse stem cells, suggesting that it may play fundamental role in helping to guide normal development.
Raising hopes for cell-based therapies, UCSF researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
Shinya Yamanaka's Nobel Prize for stem cell research brought fresh attention to something UCSF long ago sensed and seized: the promise of regeneration medicine for repairing or replacing damaged cells, tissues, and even whole organs.
Specific DNA once dismissed as junk plays an important role in brain development and might be involved in several devastating neurological diseases, UCSF scientists have found.
Stem cells of the aging bone marrow recycle their own molecules to survive and keep replenishing the blood and immune systems as the body ages, UCSF researchers have discovered.
For the first time, a clinical trial led by UCSF investigators and sponsored by Stem Cells Inc., has shown that transplanted neural stem cells appear to produce myelin in the brains of four young children with an early-onset, fatal disease.
<p>A new study that represents a significant first step in exploring the potential of stem cells to treat neurological disease is a “natural outgrowth” of a longstanding culture of interdisciplinary collaboration in UCSF neonatology — a culture that UCSF Benioff Children's Hospital physicians David Rowitch and Donna Ferriero work hard to sustain.</p>
<p>Shinya Yamanaka, MD, PhD, a senior investigator at the Gladstone Institutes and a professor of anatomy at UCSF, has won the 2012 Nobel Prize in Physiology or Medicine for his discovery of how to transform ordinary adult skin cells into cells that are capable of developing into any cell in the human body.</p>
<p>Here are answers to frequently asked questions about induced pluripotent stem cells, or iPS cells, the type of cell that has been reprogrammed from an adult cell, such as a skin or blood cell.</p>
Gladstone Institutes Senior Investigator Shinya Yamanaka, MD, PhD, a professor of anatomy at UCSF, has won the Millennium Technology Award Grand Prize, the world’s largest and most prominent technology award.
Scientists at the Gladstone Institutes have for the first time transformed skin cells — with a single genetic factor — into cells that develop on their own into an interconnected, functional network of brain cells.
<p>Medical geneticist Ophir Klein's studies of stem cells in tooth development and of stem cell changes in the gut may lead to new strategies for regenerating teeth and for treating craniofacial abnormalities.</p>
<p>A cure for sickle cell anemia and other life-threatening genetic disorders that arise in the blood is the goal of a new $6.7-million, five-year research project headed by UCSF scientist Y. W. Kan, a pioneer of modern genetics and the diagnosis of genetic diseases before birth.</p>
Stem cell transplantation may hold the promise to treating many diseases before birth such as sickle cell anemia and muscular dystrophy. But first, researchers need to overcome many barriers, including rejection of stem cell transplants by the fetus. MacKenzie’s lab recently discovered that mothers’ T cells are responsible for rejecting the grafts and that this rejection may be avoided by using stem cells from the mother.
<p>Scientists are making great strides in figuring out how the human brain develops, which are leading to novel ideas about the causes of a range of brain disorders, and are raising hopes for the regeneration of tissue that is lost in diseases such as Alzheimer’s. </p>
UCSF researchers have tackled a decade-long scientific conundrum, and their discovery is expected to lead to significant advances in using stem cells to treat genetic diseases before birth.
For patients with glioma, the most common primary brain tumor, new findings may explain why current therapies fail to eradicate the cancer. A UCSF-led team of scientists has identified for the first time that progenitor rather than neural stem cells underly a type of glioma called oligodendroglioma.
Ophir Klein wants to use stem cells to grow teeth. Because teeth are simple in comparison to large, vital organs, they may serve as a proving ground for regenerative medicine.
<p>Scientists this week are moving into the headquarters for the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at UCSF, where they will continue to advance a field transformed by the revolutionary achievement of Shinya Yamanaka.</p>
UCSF scientists have received two grants from the California Institute for Regenerative Medicine to refine their human embryonic stem cell-based strategies for treating neurological diseases and liver failure.
The National Institutes of Health (NIH) on September 30 announced 52 highly competitive awards for high-risk, high-payoff research for young biomedical scientists, and UCSF tops California institutions with four recipients.
The UCSF Diabetes Center symposium marks its 10th anniversary.
A UCSF-led team has discovered at least one key reason why blood stem cells are susceptible to developing the genetic mutations that can lead to adult leukemia.
A UCSF-led team has discovered a direct link between an inherited genetic mutation, a set of developmental abnormalities and a rare form of childhood leukemia called juvenile myelomonocytic leukemia, or JMML.
A new study by UCSF cardiologists and researchers found that high concentrations of cocoa flavanols decrease blood pressure, improve the health of blood vessels and increase the number of circulating angiogenic cells in patients with heart disease. The findings indicate that foods rich in flavanols – such as cocoa products, tea, wine, and various fruits and vegetables – have a cardio-protective benefit for heart disease patients.
UCSF scientists have discovered a new stem cell in the developing human brain. The cell produces nerve cells that help form the neocortex - the site of higher cognitive function -- and likely accounts for the dramatic expansion of the region in the lineages that lead to man, the researchers say.
UCSF scientists report that they were able to prompt a new period of “plasticity,” or capacity for change, in the neural circuitry of the visual cortex of juvenile mice.