Structure of Key Pain-Related Protein Unveiled
In a technical tour de force, UCSF scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
University of California San Francisco
Give to UCSFIn a technical tour de force, UCSF scientists have determined, at near-atomic resolution, the structure of a protein that plays a central role in the perception of pain and heat.
Carlin Senter, MD, leader of UCSF’s concussion program, answers some frequently asked questions about this common brain injury.
A team led by UCSF scientists has identified the disruption of a single type of cell – in a particular brain region and at a particular time in brain development – as a significant factor in the emergence of autism.
UCSF, a world-renowned center for the treatment of movement disorders, is holding an event to celebrate the program’s recognition by the Bachmann-Strauss Foundation as one of three new Centers of Excellence in the field.
Eleven leading scientists from the California Institute for Quantitative Biosciences (QB3) presented their latest aging research findings and anti-aging strategies at a daylong symposium called “The Science of Staying Younger Longer.”
New research by scientists at UC San Francisco shows that one of the brain’s fundamental self-protection mechanisms depends on coordinated, finely calibrated teamwork among neurons and non-neural cells.
Scientists at UCSF are reporting that they have found a way to reverse some of the negative effects of aging on the brain, using a video game designed to improve cognitive control.
A protein at the center of Parkinson’s disease research now also has been found to play a key role in causing the destruction of bacteria that cause tuberculosis.
Quick changes in behavior, in worms, at least, can be triggered by a unique form of the molecule RNA acting within the nucleus of a cell, researchers at UCSF have discovered.
Mice given cocaine showed rapid growth in new brain structures associated with learning and memory, according to a research team from the Ernest Gallo Clinic and Research Center at UCSF.
UCSF scientists working in the lab used a chemical found in an anti-wrinkle cream to prevent the death of nerve cells damaged by mutations that cause an inherited form of Parkinson’s disease.
An international study on epilepsy has uncovered 25 new mutations on nine key genes that could pave the way to develop precise therapies for a devastating form of the disorder during childhood.
Scientists at the UCSF-affiliated Gladstone Institutes have discovered that the progression of neurodegenerative disease is not due to the buildup of brain toxins itself, but rather in the individual neurons’ ability to dissolve them.
Sensory processing disorders are more prevalent in children than autism. In a groundbreaking new study, UCSF researchers have for the first time shown a biological basis for the disease in the brain structure.
UCSF scientists discussed their work in developing software, apps and online tools to help veterans with PTSD and brain injuries at the annual "Brain at War" symposium.
Using an innovative brain-tracing technique, scientists have found a way to untangle the complex connections that influence specific brain functions.
A UCSF-led team has discovered a sensory system in the foreleg of the male fruit fly that answers a central problem in evolution that is poorly understood: how animals of one species know not to mate with animals of other species.
A UCSF-led research team has identified the likely genetic mechanism that causes some patients with multiple sclerosis to quickly progress to a debilitating stage of the disease while other patients progress much more slowly.
Gene mutations that lead to major birth defects may also cause subtle disruptions in the brain that contribute to psychiatric disorders such as schizophrenia, autism and bipolar disorder, according to new research by UCSF scientists.
A key type of human brain cell developed in the laboratory grows seamlessly when transplanted into the brains of mice, UCSF researchers have found.
Epilepsy that does not respond to drugs can be halted in adult mice by transplanting a specific type of cell into the brain, UCSF researchers have discovered, raising hope that a similar treatment might work in severe forms of human epilepsy.
A Phase 2 clinical trial testing a new protocol for treating a relatively rare form of brain cancer, primary CNS lymphoma, may change the standard of care for this disease, according to UCSF doctors who led the research.
Electroencephalogram, which measures and records electrical activity in the brain, is a quick and efficient way of determining whether seizures are the cause of altered mental status and spells, according to a UCSF study.
<p>A team of researchers at UCSF has uncovered the neurological basis of speech motor control, the complex coordinated activity of tiny brain regions that controls our lips, jaw, tongue and larynx as we speak.</p>
William Seeley maps the path of frontotemporal dementia through the brain, correlating specific damage with behavioral change. By studying the disease from self to circuits to cells, this visionary neurologist searches for inroads to treatment.
<p>UCSF neuroscientists have found that by training on attention tests, people young and old can improve brain performance and multitasking skills.</p>
<p><span>Research has shown that women are at greater risk of post-traumatic stress disorder (PTSD) than men. Now, scientists based at the UCSF-affiliated San Francisco Veterans Affairs Medical Center (SFVAMC) have found that women with the condition might be more likely to experience faster aging at the cellular level and increased risk for diseases of aging than men with PTSD.</span></p>
Scientists at the UCSF-affiliated Gladstone Institutes have discovered that an FDA-approved anti-epileptic drug reverses memory loss and alleviates other Alzheimer’s-related impairments in an animal model of the disease.
Raising levels of the neurotransmitter dopamine in the frontal cortex of the brain significantly decreased impulsivity in healthy adults, in a study conducted by researchers at the Ernest Gallo Clinic and Research Center at the University of California, San Francisco.
Scientists at the Gladstone Institutes have unraveled a process by which depletion of a specific protein in the brain contributes to the memory problems associated with Alzheimer’s disease. These findings provide insights into the disease’s development and may lead to new therapies that could benefit the millions of people worldwide.