CRISPR Gene Editing Makes Stem Cells ‘Invisible’ to Immune System
UCSF scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally “invisible” to the immune system.
University of California San Francisco
Give to UCSFUCSF scientists have used the CRISPR-Cas9 gene-editing system to create the first pluripotent stem cells that are functionally “invisible” to the immune system.
UCSF researchers created a chimpanzee brain “organoids” that mimic the development and organization of full-size brains.
UCSF researchers have for the first time transformed human stem cells into mature insulin-producing cells, a major breakthrough in the effort to develop a cure for type 1 (T1) diabetes.
A growing number of researchers at UCSF and elsewhere have turned their attention to questions around why and how some people who age thrive and are more resilient than others.
From sensory processing disorder to how CRISPR is being explored to bring new treatments to patients, these are the stories that most engaged our readers in 2018.
Scientists at UCSF and Boston Children’s Hospital have developed a new technique for making mice with brains that combine the genetics of two different mouse strains.
Experiments using parasitic worms in the mouse gut have revealed a surprising new form of wound repair, a finding that could help scientists develop ways to enhance the body’s natural healing abilities.
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
UCSF scientists have shown that in the human hippocampus neurogenesis declines throughout childhood and is undetectable in adults.
UCSF received more than $593.9 million in federal funding from the National Institutes of Health in 2017 for research across multiple health-science arenas at the University.
Loss of an enzyme that modifies gene activity to promote brain regeneration may be partly responsible for age-related cognitive decline, according to new research in laboratory mice by UCSF.
Many researchers have long assumed that most stem cells in the body can produce new cells indefinitely, but new research at UCSF shows that this is not the case in the brain.
UCSF bioengineers have shown that many of the complex folded shapes that form mammalian body plans and internal tissue structures can be recreated with very simple instructions.
Whether you are seeing them for the first time or coming back for another look, check out the most popular scientific stories from UC San Francisco from the past year.
UCSF have taken the first step toward a comprehensive atlas of gene expression in cells across the developing human brain.
Researchers at UCSF have developed a new genetic model of autism, using neurons created in the lab from patients’ own skin cells.
Encellin obtained exclusive rights from UCSF for a proprietary cell encapsulation technology aimed at improving physicians’ ability to perform cell transplants without the need for immunosuppressive drugs.
UCSF Benioff Children’s Hospitals will pioneer stem cell transplants for a uniquely challenging patient population: second-trimester fetuses stricken with a potentially fatal disease.
A virus hiding quietly in the gut may trigger the onset of a severe complication known as graft-versus-host disease (GvHD) in patients who receive bone marrow transplants.
Organoids serve as dioramas of disease, allowing UCSF scientists to understand how and why problems occur during tissue development. It's also a small step toward the creation of full-sized organs we could use for transplant.
In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells, directly trigger stem cells in the skin to promote healthy hair growth.
By piercing liver cells with rapid pulses of electricity, scientists at UC San Francisco have demonstrated an entirely new way to transplant cells into organs to treat disease.
UCSF researchers are looking to the front teeth of mice to to help understand how stem cells know when it’s time for them to expand in numbers and transform into mature, adult cells in order to renew injured or aging tissue.
Studying brain disorders is complicated for many reasons, not the least being the ethics of obtaining living neurons. To overcome that obstacle, UCSF postdoc Aditi Deshpande is starting with skin cells.
A molecular key to aging of the blood and immune system has been discovered in new research conducted at UCSF.
Research uses brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of MDS, a rare genetic disorder that causes fatal brain malformations.
UCSF researchers are working to figure out how mouse stem cells divide and differentiate into acinar cells to rebuild the salivary gland after an injury. Such research could apply to patients who often lose the ability to produce saliva after undergoing radiation therapy for head and neck cancers.
UC San Francisco researchers have visualized the earliest stages of pregnancy in unprecedented detail in laboratory animals and human tissue using new laboratory imaging techniques.
UCSF researchers found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with implications for assisted reproduction, regenerative medicine, aging and cancer.
A microscopic image of a mouse leg that has been reconstructed with a stem cell transplant shows what may one day help patients regrow new muscle after a major surgery.