Archive: How Computers are Searching for Drugs of the Future
Researchers at UCSF and elsewhere are turning to virtual experiments for the initial steps of drug development.
University of California San Francisco
Give to UCSFResearchers at UCSF and elsewhere are turning to virtual experiments for the initial steps of drug development.
Americans of South Asian descent are twice as likely as whites to have risks for heart disease, stroke and diabetes, when their weight is in the normal range.
Smoking by either parent helps promote genetic deletions in children that are associated with the development and progression of the most common type of childhood cancer, according to research headed by UCSF.
UCSF researchers have used data-mining computational tools to identify a treatment for hepatocellular carcinoma, a cancer associated with underlying liver disease and cirrhosis that often only becomes symptomatic when it is very advanced.
A newly approved drug that is the first to reflect the current scientific understanding of multiple sclerosis is holding new hope for the hundreds of thousands Americans living with the disease. It also highlights the importance of clinician scientists like UCSF’s Stephen Hauser who are working to transform research into cures for patients.
An innovative virtual glucose management service for hospitalized patients with diabetes is highly effective at maintaining appropriate glucose levels.
UCSF researchers have helped to identify the three evolutionary steps the polio virus used to evolve from harmless vaccine into a regional menace. With the new knowledge, they have developed a new polio vaccine that should be unable to escape and cause outbreaks.
UCSF was the top public recipient of biomedical research grants from the National Institutes of Health or the sixth consecutive year in 2016, and the second-highest recipient among all public and private institutions nationwide.
Learn more about some of the UCSF researchers who received the top funding from the National Institutes of Health in 2016.
UCSF has worked strategically with community partners in the SFHIP to enact high-impact policies, such as banning sugar-sweetened beverages from hospitals, to improve public health and reduce health inequities in the city.
Using video microscopy in the living mouse lung, UC San Francisco scientists have revealed that the lungs play a previously unrecognized role in blood production.
Location-tracking apps on smartphones could be used to help track and manage care for thousands of patients who suffer from chronic diseases, and possibly provide feedback to them on lifestyle changes.
Researcher Annesa Flentje is looking at ways stress among sexual minorities – those whose sexual orientation, identity or practices differ from the majority – can affect physical and mental health, starting at the genetic level, with a particular focus of late on the effect of stress on HIV-positive men.
Neuroimaging is helping to distinguish between depression and dementia – two diseases with overlapping symptoms that can be difficult to diagnose properly.
Studying brain disorders is complicated for many reasons, not the least being the ethics of obtaining living neurons. To overcome that obstacle, UCSF postdoc Aditi Deshpande is starting with skin cells.
UCSF is the lead institution on a California-based, six-university consortium that was awarded $12 million by the NIDCR to develop strategies for treating craniofacial and dental defects.
Sharks, rays and skates can hunt for prey hidden in the sandy sea floor by “listening” for faint traces of bioelectricity – they can literally sense their prey’s heart beating.
In an unprecedented leap from lab to patients, a potential treatment for childhood epilepsy identified in experiments with zebrafish.
New research is paving the way to a precision medicine approach to the diagnosis and treatment of patients with traumatic brain injury.
A molecular key to aging of the blood and immune system has been discovered in new research conducted at UCSF.
A picture may be worth a thousand words. But new imaging technology that harmonizes mighty and distinctive microscopes may tell a complex story about a disease or condition – how it develops and how it can be treated precisely
The mammalian placenta is a sort of armored car protecting a developing fetus. All manner of infectious agents attempt to break in, but few of them can. Scientists are working to understand why some infections do break through and how to stop them.
The chromosomal “balance” of normal and abnormal versions of the cancer-driving gene KRAS affects the response to targeted treatments.
A type of herpes virus that infects about half of the U.S. population has been associated with risk factors for type 2 diabetes and heart disease in normal-weight women aged 20 to 49.
The genome of the single-celled organism Stentor, recently sequenced by researchers, may help lead to new insights about how to help our own cells and tissues recover from injury.
A $22 million investment via California State Assembly Bill 2664 is supporting innovation and entrepreneurship at UC San Francisco and across the University of California system.
Scalp cooling can lessen some chemotherapy-induced hair loss – one of the most devastating hallmarks of cancer – in certain breast cancer patients, according to a new multicenter study from UCSF, Weill Cornell Medicine and three other medical centers.
Research uses brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of MDS, a rare genetic disorder that causes fatal brain malformations.
UCSF’s Resource Allocation Program, which offers a single online application process for a wide variety of intramural funding opportunities, is now inviting applications for the Spring 2017 cycle.