Findings Reversed in Those with Extreme Obesity, UCSF-Led Study Shows
A type of herpes virus that infects about half of the U.S. population has been associated with risk factors for type 2 diabetes and heart disease in normal-weight women aged 20 to 49, according to a new UC San Francisco-led study.
A research team, headed by first author Shannon Fleck-Derderian, MPH, of the UCSF Department of Pediatrics, and senior author Janet Wojcicki, PhD, MPH, associate professor of pediatrics and epidemiology at UCSF, found that women of normal weight who were infected with cytomegalovirus (CMV), which typically causes no evident symptoms, were more likely to have metabolic syndrome. This condition includes risk factors such as excess abdominal fat, unhealthy cholesterol and blood fat levels, high blood pressure and elevated blood glucose.
In contrast, women infected with CMV who also had extreme obesity – defined as a body mass index (BMI) of at least 40 – were unexpectedly less likely to have metabolic syndrome than women with extreme obesity who were not infected with CMV.
The study appears Feb. 23 in the journal Obesity.
Weight Predicts Metabolic Syndrome in CMV-Positive Women
“The likelihood that women infected with CMV will have metabolic syndrome varies dramatically, depending on the presence, absence and severity of obesity,” Fleck-Derderian said. The UCSF research team did not find these same associations between CMV and metabolic syndrome in the men included in the study.
Scientific evidence indicates that metabolic syndrome may be triggered by long-acting, low-intensity inflammation. But while studies have implicated obesity in chronic inflammation, a large minority of individuals with obesity do not develop metabolic syndrome, and many normal-weight individuals do, leading researchers to search for additional drivers of chronic inflammation that also may influence risk for developing metabolic syndrome.
Chronic infection is one such suspect and in some previous studies CMV infection has been associated with inflammatory conditions, like inflammatory bowel and blood vessel diseases.
Fleck-Derderian and co-authors Wojcicki and William McClellan, MD, MPH, a professor of medicine and epidemiology at Emory University in Atlanta, examined nationwide data for 2,532 individuals between the ages of 20 and 49 years old, collected from 1999 through 2004 as part of the National Health and Nutrition Examination Survey. In a cross-sectional analysis, the researchers compared associations between CMV and components of metabolic syndrome in individuals grouped by normal weight (BMI between 18.5 and 24.9), overweight (BMI between 25 and 29.9), obesity (BMI between 30 and 39.9) and extreme obesity, while adjusting results to correct for the potential influence of age, ethnicity and poverty.
The study found that 4.9 percent of normal-weight women infected with CMV had three or more risk factors associated with metabolic syndrome, compared to less than 1 percent of their uninfected counterparts. Approximately 27.4 percent of these CMV-infected women also had lower levels of HDL “good” cholesterol, compared to 18.6 percent of their uninfected counterparts. In contrast, among women with extreme obesity 56.2 percent of those infected with CMV had three or more risk factors associated with metabolic syndrome, compared to 82.6 percent of their uninfected counterparts. These heavier, infected women had higher levels of good cholesterol and lower levels of triglycerides, a type of blood fat that is a risk factor for heart disease and typically is elevated in individuals with metabolic syndrome.
Virus May Protect Obese Women
Despite the obesity-dependent associations between CMV and metabolic syndrome identified in this study, metabolic syndrome remains much more common in women with extreme obesity in comparison to those of normal weight, the study authors emphasized.
“Women who have extreme obesity may be metabolically different from others, and CMV infection might confer some kind of protection for them against the harmful effects we generally associate with excess body fat,” Wojcicki said.
The researchers speculated that hormonal factors might help explain the different results observed in men and women, and in women with extreme obesity versus normal-weight women. They also noted that there was no data in the study regarding potential differences in CMV re-activation or re-infection rates in men versus women, which may affect development of metabolic syndrome.
Additional research is needed to identify biological mechanisms that underlie associations between CMV and risk for metabolic syndrome, and to investigate associations between CMV infection and cardiovascular disease and death in older individuals, according to the study authors.
UC San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It includes top-ranked graduate schools of dentistry, medicine, nursing and pharmacy; a graduate division with nationally renowned programs in basic, biomedical, translational and population sciences; and a preeminent biomedical research enterprise. It also includes UCSF Health, which comprises top-ranked hospitals, UCSF Medical Center and UCSF Benioff Children’s Hospitals in San Francisco and Oakland – and other partner and affiliated hospitals and healthcare providers throughout the Bay Area.