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Down Syndrome, Like Alzheimer’s, Is a Double-Prion Disorder

The brains of people with Down syndrome develop the same neurodegenerative tangles and plaques associated with Alzheimer’s disease and frequently demonstrate signs of the neurodegenerative disorder in their forties or fifties. A new study shows that these tangles and plaques are driven by the same amyloid beta (Aß) and tau prions as Alzheimer’s disease.

Microscopy of blue cells with clumps of yellow proteins, indicating contact with prion forms of amyloid beta

$147M Grant Will Address Imbalances in Alzheimer’s Study

A $147 million grant will expand diversity among Alzheimer’s disease research participants, and involve partners from UCSF, the San Francisco VA Medical Center, and the Northern California Institute for Research and Education.

An MRI technician looks at brain scans in the foreground, while a subject is inside an MRI

Non-Opioid Compounds Squelch Pain Without Sedation

A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.

Animated pills on a blue background

LSD-Like Molecules Counter Depression Without the Trip

Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.

3D computer model of the 5HT2a receptor