UCSF Receives Major Award to Speed Drug Development with AI
With the help of up to $30M in funding, researchers led by UCSF’s James Fraser, PhD, will use AI to map drug “anti-targets,” aiming to speed up drug development and reduce costs.
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How Doxycycline for STI Prevention Affects the Gut Microbiome
A new study on doxy-PEP sheds light on whether people who are regular users become resistance to this treatment, which often serves as a “morning after” pill to prevent sexually transmitted diseases.
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Precision Breast Cancer Trial Shows Improved Treatment by Tumor Subtype
Breast cancer is the second leading cause of cancer deaths in the U.S. and worldwide, pointing to the continuing need to improve treatment strategies and therapies that better patient survival and
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Why Breathing Reduces Anxiety and Boosts Our Mood
A talk on how breathing affects our mood took first place at this year's Postdoc Slam event, which is held in celebration of National Postdoc Appreciation Week.
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A Molecular Signal Works its Magic from Inside a Straitjacket
Powerful electron microscopy and 3D imaging leads scientists to a new discovery showing how the TGF-Beta signaling protein is able to move much more freely than previously thought.
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New Hope for Progressive Supranuclear Palsy with Innovative Trial
A clinical trial that will test three drugs concurrently, and could include more, represents new hope for patients with progressive supranuclear palsy (PSP), an incurable neurodegenerative disorder that usually kills within seven years after symptoms start.
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Cracking Codes in Cellular Communication
Aashish Manglik delivered the 29th annual Byers Award Lecture titled “Signal Reception: Cracking Codes in Cellular Communication.”
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Could This New Drug Turn Back the Clock on Multiple Sclerosis?
Scientists at UCSF and Contineum Therapeutics have developed a drug that spurs the body to replace the protective insulation around nerve cells, myelin, that is lost in multiple sclerosis. If it works in people, it could be a way to reverse the damage caused by the disease.
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Healthy Diet with Less Sugar Is Linked to Younger Biological Age
Added sugar in diet can speed up epigenetic aging, while a sustained, healthy diet with can slow it down and possibly reverse biological aging.
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Scientists Discover a New Hormone that Can Build Strong Bones
A newly discovered hormone explains why females can maintain bone density during lactation, when calcium is stripped away to make milk. This discovery could one day have applications to treating fractures, osteoporosis, and other bone diseases.
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New Study Shows Medication Abortion Without Ultrasound To Be Safe
Ultrasound is not necessary for medication abortion, and patients do equally well whether they are seen in person or via telehealth, and whether they receive their medication in person or through a mail order pharmacy.
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Genetic Testing Is the Key to Our Health Secrets
Our genome may one day serve as a passport guiding our health care – from cradle to grave.
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Blood Tests for Cancer Detection Aren’t Yet Ready for Prime Time
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A Drug to Slow Alzheimer’s Is Finally Available. How Are Patients Faring?
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Feeling Rough After Your COVID Shot? Congrats, It’s Working!
Adverse symptoms from the COVID-19 vaccine such as chills and headaches are linked to a robust antibody response, indicating increased efficacy compared with recipients who did not experience side effects.
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How the Cell Cycle Orchestra Plays an Unexpected New Tune
Multiciliated cells, cells with hundreds of hair-like structures that move called cilia, keep things like mucus in the lungs and cerebrospinal fluid in the brain flowing in the right direction.
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Sending Abortion Pills Through the Mail is Timely and Effective
Research found that using a mail-order pharmacy to deliver abortion medication after an in-person assessment was both safe and effective, offering privacy, convenience, and accessibility.
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Boyce, Giacomini, Narlikar, and Powe Elected to the American Academy of Arts & Sciences
Image From left to right: W. Thomas Boyce, MD; Kathy Giacomini, PhD; Geeta Narlikar, PhD; and Neil Powe, MD, MPH, MBA. Four scientists and
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The U.S. Supreme Court Weighs Mifepristone for Abortion Care
An upcoming Supreme Court ruling could put a stop to telehealth abortion services nationally, and limit access to mifepristone, one of two drugs commonly used in abortion care.
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Can a New Drug Candidate Cure Pancreatic Cancer?
A new drug candidate permanently modifies a wily cancer-causing mutation, paving the way for making pancreatic cancer treatable, or perhaps even curable.
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Better Way to Deliver Fetal Therapy for Serious Genetic Disorders
Delivering medicine through amniotic fluid is as effective as delivering it to the fetal brain via cerebrospinal fluid to treat serious disordrs such as Angelman syndrome.
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How AI Can Help Spot Early Risk Factors for Alzheimer’s Disease
UCSF scientists found a way to predict Alzheimer’s disease up to seven years before symptoms appear by analyzing patient records with machine learning. Conditions that most influenced prediction of Alzheimer’s were high cholesterol and, for women, osteoporosis.
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Bowes Biomedical Investigator Takes Aim at Cracking Cellular Communication Code
Biophysicist Aashish Manglik, MD, PhD, is the newly awarded 2024 Bowes Biomedical Investigator. With the award, he hopes to further the intersection of his GPCR research and neuropsychiatric diseases.
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How Much Advil Is Too Much?
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Genetic Discovery Reveals Who Can Benefit from Preterm Birth Therapy
In a first, scientists at UCSF and Stanford identified genetic variants that predict whether a patient is likely to respond to treatment for preterm birth. Screening for mutations could allow doctors to target medications to those most likely to benefit. No medication is currently available in the U.S. to treat preterm birth.
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Could Two Drugs Be Better Than One for Treating Prostate Cancer?
Combining testosterone-blocking drugs in patients with prostate cancer relapse prevents the spread of cancer better than treatment with a single drug.
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Should I Take Paxlovid if I Get COVID? Here’s What to Know.
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Survey Shows Physicians Don’t Understand FDA’s Approval Process
Many physicians are unfamiliar with how the Food and Drug Administration’s (FDA) regulates new drugs and medical devices, and they may be under the impression that the data supporting these approvals
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Study Finds Paxlovid Treatment Does Not Reduce Risk of Long COVID
A team of researchers from UC San Francisco has found that Paxlovid did not reduce the risk of developing long COVID for vaccinated, non-hospitalized individuals during their first COVID-19 infection.
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Corporate Strategy, National Tragedy
UCSF’s industry archives expose the marketing tactics that fueled the opioid epidemic.
