Diverse Drug-Resistant Cancer Cells Share a Hidden Weakness
UCSF researchers have discovered a gene vulnerability that could let oncologists wipe out drug-resistant cancers across many different cancer types.
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University of California San Francisco
Give to UCSFUCSF researchers have discovered a gene vulnerability that could let oncologists wipe out drug-resistant cancers across many different cancer types.
UCSF has ranked in the top 10 for seven specialties in 2017 Best Global Universities rankings released Tuesday by U.S. News & World Report.
A new test that combines the effects of more than two dozen genetic variants, does a better job of predicting which cognitively normal older adults will go on to develop Alzheimer’s dementia than testing for APOE E4.
Genetic testing and new gene therapies may raise new questions for patients, and as front-line health workers, nurses could be the ones answering questions about how they related to health. UCSF has created a new course to help give an overview of the emerging topic.
Research team led by University of California scientists has used a modified version of the gene-editing technique CRISPR to find enhancers by prompting them into action.
UCSF Benioff Children’s Hospitals will pioneer stem cell transplants for a uniquely challenging patient population: second-trimester fetuses stricken with a potentially fatal disease.
A team of UCSF researchers will receive $11.7 million over four years from the National Institutes of Health to launch a new Program in Prenatal and Pediatric Genomic Sequencing at UCSF.
A new study by UCSF researchers raises a red flag against adding antibiotics when growing cells in labs, finding that it can induce unintentional genetic changes in the cells and distort test results.
Rare deletions or duplications of about 600 genetic “letters” in a region on chromosome 16 confer a high risk of autism spectrum disorders (ASDs) and other neurodevelopmental conditions.
A genome sequencing test developed at UCSF that can rapidly pinpoint the cause of a bacterial, viral, fungal or parasitic infection is now available to help physicians nationwide diagnose cases.
A molecular test can pinpoint which patients will have a very low risk of death from breast cancer even 20 years after diagnosis and tumor removal, according to a new clinical study led by UCSF in collaboration with colleagues in Sweden.
A new study by UCSF researchers revealed the intriguing possibility that HP1α binds to stretches of DNA and pulls it into droplets that shield the genetic material inside from the molecular machinery of the nucleus that reads and translates the genome.
UCSF researchers have drawn a link between genetic abnormalities in neurodegenerative diseases and the formation of RNA foci, work the scientists said may open avenues to the development of new drug treatments.
Researchers made a significant advance, identifying the first “high-confidence” risk gene for Tourette disorder as well as three other probable risk genes.
UCSF researchers have used data-mining computational tools to identify a treatment for hepatocellular carcinoma, a cancer associated with underlying liver disease and cirrhosis that often only becomes symptomatic when it is very advanced.
Christina Hueschen took home the top prize at this year’s UCSF Grad Slam competition for her talk titled “How to Build an Elephant.”
Researcher Annesa Flentje is looking at ways stress among sexual minorities – those whose sexual orientation, identity or practices differ from the majority – can affect physical and mental health, starting at the genetic level, with a particular focus of late on the effect of stress on HIV-positive men.
The chromosomal “balance” of normal and abnormal versions of the cancer-driving gene KRAS affects the response to targeted treatments.
A novel gene therapy treatment may save infants from SCID, a devastating immune disorder commonly known as "bubble boy disease".
The genome of the single-celled organism Stentor, recently sequenced by researchers, may help lead to new insights about how to help our own cells and tissues recover from injury.
A nationwide project that includes two UCSF researchers will use the latest technology, including gene editing, to gain insights into human biology that could one day lead to treatments for complex genetic diseases.
A new study identified genetic predictors of normal prostate-specific antigen (PSA) levels in healthy men, which could be used to improve the accuracy of PSA-based prostate cancer screening tests.
Distinct sets of genetic defects in a single neuronal protein can lead either to infantile epilepsy or to autism spectrum disorders.
Study suggests, genetic variants that have distinct effects on physical traits in men versus women are also linked to men’s and women’s risk for a range of diseases – autism, multiple sclerosis, type 1 diabetes.
UCSF study demonstrates that nucleosomes actively change their shape as part of the larger process of epigenetic regulation of gene expression.
Mitochondrial replacement therapy now has been used in humans to conceive a “three-parent baby” to prevent inherited mitochondrial disorders, but there remain questions about the effectiveness of the process.
Children with severe cases of epilepsy such as Dravet syndrome are finding new and unexpected cures thanks to determined pediatricians and translational research at UCSF.
A UC San Francisco-led study has identified signatures of ethnicity in the genome that appear to reflect an ethnic group’s shared culture and environment, rather than its common genetic ancestry.
UCSF researchers have discovered a way to switch off the widely used CRISPR-Cas9 gene-editing system using newly identified anti-CRISPR proteins that are produced by bacterial viruses.