Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
Using a protocol developed at UCSF, physicians have successfully treated a fetus with a devastating genetic disorder for the first time, and the child is now thriving as a toddler.
University of California San Francisco
Give to UCSFUsing a protocol developed at UCSF, physicians have successfully treated a fetus with a devastating genetic disorder for the first time, and the child is now thriving as a toddler.
Cystic fibrosis is missed more often in newborn screenings for non-white than white babies, creating higher risk for irreversible lung damage and other serious outcomes in Black, Hispanic, Asian, American Indian and Alaska Native newborns.
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
A new "subway map" of immune networks connects gene variation to risk for autoimmune disease.
A world-class team of researchers co-led by UCSF’s Allan Balmain, PhD, FRS, has been selected to receive a $25 million Cancer Grand Challenges award to investigate the very early stages of cancer development.
Nevan Krogan, PhD, director of UCSF’s Quantitative Biosciences Institute, examines in detail the effects of a handful of genes that seem to play an outsize role in a wide array of diseases.
Wei Gordon was among nine finalists in the sixth annual UCSF Grad Slam, held March 31 – after a two-year hiatus due to the pandemic – competing to inform and entertain with three-minute talks based on their own research.
Brain tumor patients survived longer when treated aggressively with surgery, radiation and chemotherapy. Now, a UCSF study underscores the critical role of genomic profiling in diagnosing and grading brain tumors.
Stephen L. Hauser, MD, Professor of Neurology and Director of the UCSF Weill Institute for Neurosciences, has been chosen by the American Brain Foundation (ABF) to receive its second annual Scientific Breakthrough Award.
Not everyone needs 8 hours of sleep, say UCSF researchers. Some lucky people are “elite sleepers,” packing sleep’s benefits into 4 to 6 hours a night. Their genes may hold clues to how efficient sleep can fend off dementia.
UCSF researchers successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.
A new fast-track review for UCSF gene therapy could help more kids with deadly Artemis-SCID disease get life-saving treatment sooner.
The new Weill Neurosciences Building, designed to foster connections among scientists and clinicians in neurology, neurosurgery and psychiatry, will serve as a global destination for researchers to develop innovative treatments for intractable brain diseases.
UCSF’s research has been ranked among the top in the world, according to the latest U.S. News & World Report’s Best Global Universities 2022 rankings.
Two new studies of the developing human brain are helping researchers reconcile a long-held debate over how the brain forms.
A team of researchers at UCSF have recently sequenced the condor genome, shining light on the species’ history and opening the door to a better understanding of genomics in small populations, for the benefit of both condors and humans.
In the largest study of its kind, an investigation by UCSF researchers has found no evidence that moderate coffee consumption can cause cardiac arrhythmia.
The B.1.1.7 coronavirus variant—also known as Alpha—may be more infectious because it contains mutations that make it better adapted to foil the innate immune system, at least for long enough to allow the virus to replicate and potentially find new hosts, according to a new study.
Leading scientists share some of the tools and strategies that could help us better confront and contain future outbreaks.
Insomnia is miserable, and lost sleep can harm our health. Now, researchers are seeing the promise of solutions in our genes.
Cognitive behaviorial therapy for insomnia, the gold-standard intervention, also suggests benefits for well-being.
Scientists now have shown that the weakening of an astronaut’s immune system during space travel is likely due in part to abnormal activation of immune cells called T regulator cells.
Six health care experts grapple with how to address race without being racist.