In CRISPR Advance, Scientists Successfully Edit Human T Cells
In a project spearheaded by investigators at UCSF, scientists have devised a new strategy to precisely modify human T cells using the genome-editing system known as CRISPR/Cas9.
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Age-Related Cognitive Decline Tied to Immune-System Molecule
A blood-borne molecule that increases in abundance as we age blocks regeneration of brain cells and promotes cognitive decline, suggests a new study.
Specific Roles of Adult Neural Stem Cells May Be Determined Before Birth
Adult neural stem cells, which are commonly thought of as having the ability to develop into many type of brain cells, are in reality pre-programmed before birth to make very specific types of neurons.
Cancer Blocked by Halving Levels of Protein Thought To Be ‘Untouchable’
A team of UC San Francisco and Stanford University scientists has discovered that a protein thought to be crucial for the body to develop and function correctly can be reduced by half in mice with no apparent ill effects.
Escaping Ethiopia's Poverty at the School of Pharmacy
In the state of Tikray in northern Ethiopia, where poverty and unemployment are rampant, very few have the fortune to go to college. But Getahun Weldeselassie nevertheless banked on education as his best shot at a better life.
Withholding Angiotensin Receptor Blockers After Surgery Increases Risk of Postoperative Death
Withholding angiotensin receptor blockers for longer than two days after surgery is associated with a significantly increased risk of postoperative death, according to a study of more than 30,000 patients.
The Resolution Revolution: Building a Better Microscope to See at the Atomic Level
After decades of challenges, scientists have developed an imaging technique that allows them to see the detailed structure of tiny proteins — and it's changing how we think about medicine.
Evolution of Stem Cells Traced in Study of Fossilized Rodent Teeth
By studying fossilized teeth from thousands of extinct rodent species, UCSF and University of Helsinki scientists have shown how fundamental evolutionary mechanisms drive the emergence of novel mammalian stem cells.
Childhood Syndrome Combining Lung Disease, Arthritis Is Identified
A research team led by scientists from UCSF, Baylor College of Medicine, and Texas Children’s Hospital has identified a new autoimmune syndrome characterized by a combination of severe lung disease and arthritis that currently has no therapy.
Angiogenesis Inhibitors Undermined by Immune Cells, Says Study
A team led by UCSF scientists has discovered a possible reason why angiogenesis inhibitors often work in the short term but usually become ineffective within months, one that could lead to a way to prevent cancer relapse.
Some Atrial Fibrillation Patients Receive Unnecessary Blood Thinners
About a quarter of all atrial fibrillation patients at the lowest risk for stroke receive unnecessary blood thinners from cardiology specialists, according to UCSF researchers.
First Look at ‘Wasabi Receptor’ Brings Insights for Pain Drug Development
Researchers at UCSF have pulled aside the curtain on a protein informally known as the “wasabi receptor,” revealing at near-atomic resolution structures that could be targeted with anti-inflammatory pain drugs.
How Beige Fat Could Fight Obesity
For the first time, scientists have isolated beige fat in adult humans that's able to convert energy-storing white fat cells into the energy-burning kind.
Dual Therapy’s One-Two Punch Knocks Out Drug-Resistant Lung Cancer
UCSF scientists have identified a biological escape hatch that explains the resistance to targeted drug treatment in some lung cancer patients.
UMass Dartmouth, UCSF Research Demonstrates Shared Rules of Development Can Predict Patterns of Evolution in Different Species
The evolution and development of structures as diverse as limbs, fingers, teeth, somites and vertebrae may have more in common than once believed, according to a new study.