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Cancer starts with mutations in a cell’s DNA, but new UCSF research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which it grows.
UCSF researchers found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.
Tissue biologist Sarah Knox has long been fascinated with saliva. Just when she begins to doubt whether her singular passion will lead to real-world impact, an old family friend reaches out to her with a problem only she may be able to solve.
UCSF scientists have discovered a new way to control the immune system’s “natural killer” cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.
Researchers found that patients with a pediatric cancer who were protected under the ACA’s dependent coverage provision were more likely to remain on private insurance for longer durations compared to their older peers who turned 19 before the Act.
The UCSF researchers — whose work spans investigations into autism spectrum disorder (ASD), oncology, and mitochondrial disease — were among 85 awardees for the grants that the NIH says “will fund highly innovative and unusually impactful biomedical or behavioral research proposed by extraordinarily creative scientists.”
Though cancer immunotherapy has become a promising standard-of-care treatment – and in some cases, perhaps a cure – for a wide variety of different cancers, it doesn’t work for everyone, and researchers have increasingly turned their attention to understanding why.
UCSF Medical Center has been recognized as one of the nation’s finest hospitals in the U.S. News & World Report 2020-2021 Best Hospitals survey, ranking among the top 10 hospitals nationwide for the 22nd year.
None of the individual tumor genetic differences that were identified are likely to explain significant differences in health outcomes or to prevent Black Americans from benefiting from a new generation of precision prostate cancer therapies, researchers say, as long as the therapies are applied equitably.
A new model of the causes of breast cancer, created by a team led by researchers at UCSF, Genentech and Stanford University, is designed to capture the complex interrelationships between dozens of primary and secondary breast cancer causes and stimulate further research.
Colleagues are mourning the passing of Zena Werb, PhD, a giant in the field of cancer biology whose four decades of research at UCSF informed the rise of immunotherapy and other modern approaches to cancer treatment.