Non-Opioid Compounds Squelch Pain Without Sedation
A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
University of California San Francisco
Give to UCSFA newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
UCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.
On a sunny Friday, teams of aspiring young scientists gathered in the Clinical Sciences building at Parnassus Heights to look for treasure in a trillion data points about cancer.
Researchers have found significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, showing new pathways for potential treatment.
A new therapy pulls forward a mutated version of the KRAS protein to help the immune system recognize and destroy cancer cells.
UCSF-led research outlines the comprehensive immune landscape and microbiome of pancreatic cysts as they progress from benign cysts to pancreatic cancer. Their findings could reveal the mechanism of neoplastic progression and provide targets for immunotherapy to inhibit progression or treat invasive disease.
The study, funded by the National Institute on Aging, recruited people who were 50 and older and homeless, and followed them for a median of 4.5 years. By interviewing people every six months about their health and housing status, researchers were able to examine how things like regaining housing, using drugs, and having various chronic conditions, such as diabetes, affected their risk of dying.
When our eyes move during REM sleep, we’re gazing at things in the dream world our brains have created, according to a new study by UCSF researchers. The findings shed light not only into how we dream, but also into how our imaginations work.
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
The discovery of how to shift damaged brain cells from a diseased state into a healthy one poses a potential new path to treating Alzheimer’s and other forms of dementia, according to a new study from UCSF researchers.
Blood tests taken within 24 hours of a traumatic brain injury (TBI) flag which patients are likely to die and which patients are likely to survive with severe disability, according to a study headed by UCSF, the University of Pennsylvania and the University of Michigan.
Severe restrictions and bans on abortion access may have life-changing and even life-threatening consequences in as many as 28 states for women of childbearing age with conditions like migraine, multiple sclerosis (MS) and epilepsy.
A new "subway map" of immune networks connects gene variation to risk for autoimmune disease.
A new UCSF study reveals how gut inflammation can disrupt not only the digestive system, but also the skin. It’s a tale in which the main players are specialized immune cells and the bacterial communities — called microbiomes — that dwell within the gut and skin.
A new study shows that when residents in Black communities have a stroke, they are at greater risk of receiving care at a less-resourced hospital, where their chances of recovery are slimmer.
How David Julius and Ardem Patapoutian found the molecules in our bodies that sense heat, cold, touch, and pain – and transformed sensory neuroscience.
In a new study of Alzheimer’s disease, UCSF reserachers have discovered that a relatively unstudied form of the tau protein associated with neurodegeneration may be a means for better diagnosis and treatment of the disease.
Seth Blumberg, MD, PhD, an assistant professor of medicine, is clinical specialist in infectious disease, including Monkeypox. He offers insight in the recent outbreak in a Q&A.