University of California San Francisco
Give to UCSF
Displaying 1 - 30 of 416
-
-
Children’s Hospital Oakland’s Pioneering Gene Therapy Aims to Free Patients of Blood Disease. Is a Cure at Hand?
-
Two Daughters, a Rare Blood Disorder and a Fairytale Cure
Two sisters are receiving a breakthrough, FDA-approved treatment for beta thalassemia at UCSF Benioff Children's Hospital, Oakland. This is the first real therapy other than monthly transfusions for a devastating disease that destines people to shorter lives.
-
How a Cutting-Edge Genetic Test Helps Ill Newborns, Pregnant Moms
Looking at a baby’s entire DNA sequence through rapid whole-genome sequencing (rWGS) allows doctors to diagnose and treat life-threatening diseases earlier, sometimes even in utero.
-
Oakland Hospital First in West to Pioneer Beta Thalassemia Drug
UCSF Benioff Children’s Hospital Oakland is the first hospital in the West to administer a newly approved gene therapy to treat beta thalassemia with gene therapy, reducing the need for lifelong blood transfusions.
-
Gene Mutation May Explain Why Some Don’t Get Sick from COVID-19
A common mutation can help people infected with the COVID-19 virus avoid developing any symptoms.
-
Genetic Variant Identified That May Increase Multiple Sclerosis Severity
-
Brains and Braggadocio
As part of its miniseries on Black excellence in STEM, Carry the One Radio interviewed UCSF’s Akinyemi Oni-Orisan, PharmD, PhD. The assistant professor of clinical pharmacy shares how he’s improving cardiovascular care for everyone and how he inspires confidence in himself and his students. Find it on your favorite podcast forum.
-
How Gene Therapy Saved a Child from ‘Bubble Boy’ Disease
In a breakthrough, “HT” became the first person in the world to receive gene-corrected stem cells for Artemis-SCID.
-
Personalizing Prostate Cancer Screening May Improve Accuracy of Detection
Taking into account genetic factors that can change PSA levels not associated with cancer, the screening accuracy can be improved.
-
UCSF is First in California to Provide Drug-Gene Testing
UCSF is the first hospital in California to offer pharmacogenetic testing for smarter prescribing. Testing identifies genetic makeup and tailors medications to improve efficacy and avoid lethal drug reactions.
-
Even a Brain-Eating Amoeba Can’t Hide From This Cutting-Edge Diagnosis Tech
-
What We Were Taught About RNA in High School is Only Half the Picture
Vissers’ work on RNA tags helped found the field of epitranscriptomics, the study of how chemical marks on RNA, rather than their sequence alone, dictate the function of the molecules.
-
Gene Therapy Trial Shows Promise for Treating ‘Bubble Boy’ Syndrome. Now Comes the Hard Part
-
How Gene Therapy Saved a Child from “Bubble Boy Disease”
In a breakthrough, HT became the first person in the world to receive gene-corrected stem cells for Artemis-SCID. His new immune system is life-changing.
-
The Disease Took Zara, Then Sara. Could Ayla Be Saved?
-
Fetal Therapy Offers Hope for Patients with Rare Genetic Disorders
Using a protocol developed at UCSF, physicians have successfully treated a fetus with a devastating genetic disorder for the first time, and the child is now thriving as a toddler.
-
Non-White Newborns With Cystic Fibrosis More Likely To Be Missed in Screening
Cystic fibrosis is missed more often in newborn screenings for non-white than white babies, creating higher risk for irreversible lung damage and other serious outcomes in Black, Hispanic, Asian, American Indian and Alaska Native newborns.
-
A Cellular Engineering Breakthrough: High-Yield CRISPR Without Viral Vectors
A new variation of the CRISPR-Cas9 gene editing system makes it easier to re-engineer massive quantities of cells for therapeutic applications. The approach, developed at Gladstone Institutes and UC San Francisco (UCSF), lets scientists introduce especially long DNA sequences to precise locations in the genomes of cells at remarkably high efficiencies without the viral delivery systems that have traditionally been used to carry DNA into cells.
-
Giving Immunotherapy Cells Resilience to Pass the ‘Stress Test’
T cells used in immunotherapy treatments can get exhausted and shut down by fighting cancer cells and tumors. Using a CRISPR-based edit on these cells’ genomes, researchers at UCSF and Gladstone Institutes have rendered the therapeutic cells more resilient against tumors.
-
Scientists Map Networks of Disease-Associated Immune Genes
A new "subway map" of immune networks connects gene variation to risk for autoimmune disease.
-
Understanding the Genesis of Cancer is Goal of $25 Million Award
A world-class team of researchers co-led by UCSF’s Allan Balmain, PhD, FRS, has been selected to receive a $25 million Cancer Grand Challenges award to investigate the very early stages of cancer development.
-
Navigating From the Genome to the Clinic Using ‘Cell Maps’
Nevan Krogan, PhD, director of UCSF’s Quantitative Biosciences Institute, examines in detail the effects of a handful of genes that seem to play an outsize role in a wide array of diseases.
-
Scientists Say Endangered Porpoise Isn’t Doomed – So Long as Humans Stop Killing Them
-
Talk on the Secrets of Fruit-Eating Mammals Wins 2022 UCSF Grad Slam
Wei Gordon was among nine finalists in the sixth annual UCSF Grad Slam, held March 31 – after a two-year hiatus due to the pandemic – competing to inform and entertain with three-minute talks based on their own research.
-
Genomic Sequencing Is Changing Diagnosis, Treatment for Patients with Brain Cancer
Brain tumor patients survived longer when treated aggressively with surgery, radiation and chemotherapy. Now, a UCSF study underscores the critical role of genomic profiling in diagnosing and grading brain tumors.
-
UCSF Neurologist to Receive Prestigious Scientific Award
Stephen L. Hauser, MD, Professor of Neurology and Director of the UCSF Weill Institute for Neurosciences, has been chosen by the American Brain Foundation (ABF) to receive its second annual Scientific Breakthrough Award.
-
When It Comes to Sleep, It’s Quality Over Quantity
Not everyone needs 8 hours of sleep, say UCSF researchers. Some lucky people are “elite sleepers,” packing sleep’s benefits into 4 to 6 hours a night. Their genes may hold clues to how efficient sleep can fend off dementia.
-
Treating Tough Tumors by Exploiting Their Iron ‘Addiction’
UCSF researchers successfully leveraged an FDA-approved drug to halt growth of tumors driven by mutations in the RAS gene, which are famously difficult to treat and account for about one in four cancer deaths.
-
UCSF Gene Therapy for Deadly Mutation Fast-Tracked for FDA Review
A new fast-track review for UCSF gene therapy could help more kids with deadly Artemis-SCID disease get life-saving treatment sooner.
