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‘Cellbots’ Chase Down Cancer, Deliver Drugs Directly to Tumors

UCSF scientists have engineered human immune cells that can precisely locate diseased cells anywhere in the body and execute a wide range of customizable responses, including the delivery of drugs or other therapeutic payloads directly to tumors or other unhealthy tissues.

Immune-Cell Population Predicts Immunotherapy Response in Melanoma

The abundance of a subtype of white blood cells in melanoma tumors can predict whether or not patients will respond to a form of cancer immunotherapy known as checkpoint blockade, according to a new study led by UCSF researchers and physicians.

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Gut Bacteria Linked to Rare Autoimmune Disease

A new study led by UCSF scientists shows that a bacterium commonly found in the human gut is overrepresented in patients with a rare, often disabling autoimmune disease known as neuromyelitis optica.

Researchers Map Zika’s Routes to the Developing Fetus

Zika virus can infect numerous cell types in the human placenta and amniotic sac, according to researchers at UCSF and UC Berkeley who show in a new paper how the virus travels from a pregnant woman to her fetus.

Zika Infection May Be Masked by Other Viral Infections

Symptoms of infection with the Zika virus in Brazil may be masked by simultaneous infection with other mosquito-spread viruses common in the same region — such as dengue fever and chikungunya viruses — pointing to the need for comprehensive testing, according to a study led by a UCSF expert in DNA-based diagnostics in collaboration with Brazilian researchers.

Covert Inflammation May Trigger Many Forms of Cancer

A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don’t display typical signs of inflammation.

Deadly Fungus Uses Unexpected System To Control Its Virulence

A research team led by UC San Francisco scientists has discovered a cellular signaling system that regulates the virulence of Cryptococcus neoformans, a fungus that has been estimated to cause nearly a million cases of meningitis worldwide per year, about 625,000 of which are fatal.

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UCSF Researchers Reappraise Treatment for Belly Birth Defect

UC San Francisco researchers have shed light on how the immune system of a fetus can run amok, triggering inflammation in the developing intestines that protrude outside of the body through a hole beside the belly button.

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Wrapping Up Multiple Sclerosis

With one drug to shut down its progression and another to undo its damage, plus a worldwide effort stalking the origins of multiple sclerosis, MS doesn’t stand a chance.

Dr. Stephen Hauser, examining a patient, gestures for her to look straight ahead.

Malaria-Free World Possible Within a Generation, Study Says

Global malaria eradication is possible within a generation, but only with renewed focus, new tools and sufficient financial support, according to a paper published in The Lancet by the Global Health Group’s Malaria Elimination Initiative at UCSF.