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The first results from a large international study of patients taking metformin, the world’s most commonly used type 2 diabetes drug, reveal genetic differences among patients that may explain why some respond much better to the drug than others.
Using advanced imaging technology that allowed them to spy on interactions among cells in the lymph nodes of living mice, a research team led by UCSF scientists has identified a cell that is a key player in mounting the immune system’s defense against cancer.
A previously unidentifiable type of low-grade inflammation may explain why common anti-inflammatory drugs such as aspirin have shown promise against some types of cancer – even when patients don’t display typical signs of inflammation.
A drug commonly used to treat high blood pressure has been shown to significantly reduce the risk of blocked electrical impulses to the heart and could be an effective treatment for certain types of heart disease known as conduction disease, in which the progression of electrical impulses through the heart is impeded.
When doctors accept meals from pharmaceutical salespeople, they are much more likely to prescribe the drugs the representatives are promoting than cheaper generic alternatives, UCSF researchers found .
Researchers have identified a pair of tarantula toxins that target a previously unknown pain pathway in sensory nerves.
A team of cancer researchers led by scientists at UCSF and Memorial Sloan Kettering Cancer Center in New York have developed a first-of-its-kind hybrid drug with the power to outsmart drug-resistant cancers.
With one drug to shut down its progression and another to undo its damage, plus a worldwide effort stalking the origins of multiple sclerosis, MS doesn’t stand a chance.
UCSF researchers are using big data to find cancer treatments by mapping gene networks and screening existing cancer drugs to test their effectiveness against dozens of different cancer gene variants.
UCSF scientists have created a new class of highly customizable biological sensors that can be used to form “logic gates” inside cells of the immune system, giving these cells the capability to home in on and kill a wide range of cancer cells while preventing them from attacking normal tissue.
Children and young adults with severe forms of epilepsy that does not respond to standard antiepileptic drugs have fewer seizures when treated with purified cannabinoid, according to a multi-center study led by researchers from UCSF Benioff Children’s Hospital San Francisco.
A team of researchers at UCSF has devised a new approach for early stage drug discovery that uses techniques from the world of computer vision in combination with a powerful new tool.
It is worthwhile to give patients expensive new drugs that can cure their hepatitis C much earlier than some insurers are now willing to pay for them, according to a UCSF study.
UCSF researchers has discovered that single-celled yeast have sensory biases that can be hacked by a carefully engineered illusion, a finding that could be used to develop new approaches to fighting diseases such as cancer.
Scientists at the UNC School of Medicine (UNC) and UCSF have created a general tool to probe the activity of orphan receptors, illuminating their roles in behavior and making them accessible for drug discovery.