CRISPR-Based Tool Maps Gene Function in Human Cells
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
![gene sequencing results](/sites/default/files/styles/news_card__image/public/fields/field_insert_file/news/gene%20sequencing.jpg)
University of California San Francisco
Give to UCSFUCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
A comprehensive genetic analysis of metastatic prostate cancer has, for the first time, revealed a number of major ways in which abnormal alterations of the genome propel this aggressive form of the disease.
UCSF researchers have identified the sequence of genetic changes that transform benign moles to into malignant skin cancer.
The already famous CRISPR system allows scientists to edit faulty genes by cutting and replacing sections of DNA, but new and improved CRISPR techniques developed at UCSF have expanded CRISPR’s scalpel into a Swiss Army knife.
Sensory Processing Disorder, or SPD, causes some children to find everyday stimuli excruciating. Scientists are finally shedding light on what causes the disorder and what can be done about it.
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
Each year, 300,000 infants worldwide are born with sickle cell. UCSF Benioff Children’s Hospitals are at the the leading edge of advancements to cure sickle cell disease.
The journey from discovering and developing effective, precise medications to using them correctly and safely in patients is hardly fast and easy. Nor is it a straight shot. Scientists in the UCSF School of Pharmacy are challenging the status quo every step of the way.
Researchers have demonstrated the ability to program groups of individual cells to self-organize into multi-layered structures reminiscent of simple organisms or the first stages of embryonic development.
UCSF researchers have safely transplanted a woman’s stem cells into her growing fetus, leading to the live birth of an infant with a normally fatal fetal condition.
Every day, on average, 10 new genetic tests become commercially available to help doctors and patients make more informed decisions about health care. Yet few doctors know how to navigate the tens of thousands of tests that populate the genetic testing marketplace, which prevents patients from benefiting from them.
Esteban Burchard, who arrived at UCSF in 1998, marks the 20th year of his asthma project in May. His lab, which he named the UCSF Asthma Collaboratory, has delved deep into the genetic basis of asthma and of drug response in the disease.
By studying a rare liver disease called Alagille syndrome, scientists from UC San Francisco and Cincinnati Children’s Hospital Medical Center have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.
Data from clinical studies of gene therapy in patients with transfusion-dependent Beta-Thalassemia show majority of patients are transfusion-free.
New study could make it much easier for physicians to use the genetic profile of a patient’s tumor to pick the chemotherapy treatment with the fewest side effects and best chance of success.
In a move that underscores the increasingly important role of genomics in medicine, UCSF has appointed Aleksandar Rajkovic, MD, PhD, as the first Chief Genomics Officer of UCSF Health. His appointment, which follows a national search, is effective May 1.
A new study finds that a common cancer-causing mutation in a GTPase called Gαs subverts the model for this type of growth switch in cancer.
The largest analysis to date of genetic data in ALS has identified two previously unrecognized genetic risks that are significantly associated with the disease.
Ata's appearance can most likely be explained by a handful of rare genetic mutations—some already known, others newly discovered—that are linked to dwarfism and other bone and growth disorders.
A new study in mice reveals how a gene mutation seen in human short-sleepers may allow them to survive and thrive on just a few hours of sleep.
The largest-ever whole-genome sequencing study of drug response in minority children has revealed new clues about why the front-line asthma drug albuterol does not work as well for minority children.
New research led by David Solomon, an assistant professor in the Department of Pathology at UCSF, provides much-needed targeted treatment options for patients whose tumors cannot be surgically removed.
Stretches of DNA that make us uniquely human are partly responsible for controlling neuron growth, according to new research from the Gladstone Institutes and UCSF.
UCSF researchers have discovered that the brain’s ability to regulate body weight depends on a novel form of signaling in the brain’s “hunger circuit” via antenna-like structures on neurons called primary cilia.
Severe combined immunodeficiency (SCID) if undetected can be lethal by the time a child turns 1 year old. UCSF researchers created a screening test for SCID, which impacts Navajo families at a far higher rate than the rest of the population.
UCSF is moving to make genetic testing a routine part of medical care, and one step in that direction is the opening of the Preventive Genomics Clinic.
Consumption of sugar-sweetened beverages by children between 2 and 3 years of age has been linked to shorter telomeres in a new, preliminary study by researchers from UCSF.
For the first time, researchers have infused a person’s blood with gene-editing tools, aiming to treat his severe inherited disease.
UCSF researchers are leading several initiatives that aim to see how dozens of seemingly unrelated genes and proteins involved in a disease are in fact all part the same interconnected biological pathway.
New research finds one of the world’s most deadly forms of lung cancer is driven by changes in multiple different genes.