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UCSF scientists assembled an international research team that has figured out how SARS-CoV-2, the virus that causes COVID-19, hijacks proteins in host cells that serve as master regulators of key cellular processes.
Though many hopes are hanging on the development of a vaccine or drug that targets the novel coronavirus directly, a UCSF-led team is taking an unconventional approach: target the host – in other words, you.
Researchers identified a protein that cancer cells use as a shield to protect the PI3K pathway against targeted drugs, and showed that blocking this protein allowed previously ineffective therapies to slow cancer cell growth and shrink tumors.
UCSF researchers have used data-mining computational tools to identify a treatment for hepatocellular carcinoma, a cancer associated with underlying liver disease and cirrhosis that often only becomes symptomatic when it is very advanced.