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UCSF Scientists Build a Molecular ‘GPS’ to Guide Cell Therapies

UCSF scientists have been awarded more than $30 million to develop “tissue GPS,” a new system using engineered T cells to guide therapies directly to their targets in the brain to treat neurological diseases like cancer, multiple sclerosis and Alzheimer’s.

A scientific image of T-cells attacking a glioblastoma (brain tumor).

Targeted Treatment of Rare Childhood Leukemia

Juvenile myelomonocytic leukemia (JMML) is a rare but aggressive childhood leukemia. While hematopoietic stem cell transplantation is curative for some patients, approximately half of all patients see

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In Judo Move, Scientists Use Cancer’s Strength to Fight Against It

Cancer immunotherapy is hindered by the fact that engineered immune cells often get worn out and depleted before they've killed a tumor. A UCSF team has identified mutations that give cancerous lymphoma T-cells their superpower and transfer those genes into engineered, therapeutic immune cells.

A microscopy of fluorescent T cells in a skin cancer carcionma

Dangerous Beauty

Cell biologist and engineer Matthew Kutys, PhD, and his team harness organoids – living tissues derived from patient tumors – to study how cancer spreads.

Microscopy image of human breast cancer tissue

How to Improve Survival for Pediatric Leukemia Patients

Researchers at UCSF and UC Berkeley are investigating the impact of pre- and post-natal exposures to tobacco smoke on the survival rate of children with acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML).

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