New Genetic Models of Autism Point to Cellular Roots of Disease
Researchers at UCSF have developed a new genetic model of autism, using neurons created in the lab from patients’ own skin cells.
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Innovative Type 1 Diabetes Approach Licensed to Encellin
Encellin obtained exclusive rights from UCSF for a proprietary cell encapsulation technology aimed at improving physicians’ ability to perform cell transplants without the need for immunosuppressive drugs.
Novel Treatment Aims to Transform Protocol for Deadly Blood Disorder
UCSF Benioff Children’s Hospitals will pioneer stem cell transplants for a uniquely challenging patient population: second-trimester fetuses stricken with a potentially fatal disease.
Gut Viruses Tied to Potentially Deadly Complication of Bone Marrow Transplant
A virus hiding quietly in the gut may trigger the onset of a severe complication known as graft-versus-host disease (GvHD) in patients who receive bone marrow transplants.
Sowing Stem Cells
Organoids serve as dioramas of disease, allowing UCSF scientists to understand how and why problems occur during tissue development. It's also a small step toward the creation of full-sized organs we could use for transplant.
New Hair Growth Mechanism Discovered
In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells, directly trigger stem cells in the skin to promote healthy hair growth.
Novel Surgical Technique Paves Way to Restoring Failing Organs
By piercing liver cells with rapid pulses of electricity, scientists at UC San Francisco have demonstrated an entirely new way to transplant cells into organs to treat disease.
Mouse Teeth Providing New Insights into Tissue Regeneration
UCSF researchers are looking to the front teeth of mice to to help understand how stem cells know when it’s time for them to expand in numbers and transform into mature, adult cells in order to renew injured or aging tissue.
Science in Focus: Creating Neurons from Skin Cells to Understand Autism
Studying brain disorders is complicated for many reasons, not the least being the ethics of obtaining living neurons. To overcome that obstacle, UCSF postdoc Aditi Deshpande is starting with skin cells.
UCSF Researchers Find Key to ‘Tired’ Blood and Immune Systems
A molecular key to aging of the blood and immune system has been discovered in new research conducted at UCSF.
Human Brain ‘Organoids’ Offer New Insight into Rare Developmental Disease
Research uses brain “organoids” — tiny 3D models of human organs that scientists grow in a dish to study disease — to identify root causes of MDS, a rare genetic disorder that causes fatal brain malformations.
Science in Focus: Rebuilding the Salivary Gland After Radiation
UCSF researchers are working to figure out how mouse stem cells divide and differentiate into acinar cells to rebuild the salivary gland after an injury. Such research could apply to patients who often lose the ability to produce saliva after undergoing radiation therapy for head and neck cancers.
Scientists Visualize Embryo Implantation in the Mouse Uterus in Unprecedented 3D Detail
UC San Francisco researchers have visualized the earliest stages of pregnancy in unprecedented detail in laboratory animals and human tissue using new laboratory imaging techniques.
Researchers Put Mouse Embryos in Suspended Animation
UCSF researchers found a way to pause the development of early mouse embryos for up to a month in the lab, a finding with implications for assisted reproduction, regenerative medicine, aging and cancer.
Science in Focus: Regenerating Muscle from Stem Cells
A microscopic image of a mouse leg that has been reconstructed with a stem cell transplant shows what may one day help patients regrow new muscle after a major surgery.
