Small-Molecule Drug Reverses Neural Effects of Concussion
A small molecule called ISRIB that was identified at UCSF can reverse the neuronal and cognitive effects of concussion in mice weeks after an injury occurred, new research found.
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Senescent Cells also Help to Heal Damaged Tissues
Not all senescent cells are harmful “zombies” that should be wiped out to prevent age-related disease. New research from UCSF found that some of them are embedded in young, healthy tissues and promote normal repair from damage.
Feeling Winded After Your Workout? Long COVID May Claim Another Symptom
A new study points to another persistent effect of COVID-19, identified months after infection: reduced exercise capacity.
Video Games Offer the Potential of “Experiential Medicine”
After a decade of work, scientists at UCSF’s Neuroscape Center have developed a suite of video game interventions that improve key aspects of cognition in aging adults.
Fewer Asian, Black, Hispanic Patients Eligible for Drugs That May Delay Alzheimer’s Progression
A new study shows that fewer Black, Hispanic and Asian patients would qualify for these treatments that may slow Alzheimer’s progression, since cognitive impairment in these groups is more likely to be caused by other forms of dementia that may be unrelated to amyloid plaques.
Non-Opioid Compounds Squelch Pain Without Sedation
A newly identified set of molecules alleviated pain in mice while avoiding the sedating affect that limits the use of opiates, according to a new study led by researchers at UC San Francisco.
UCSF Researchers Discover How Vascular Cells Develop in Prenatal Brain
UCSF has revealed how blood vessel cells develop in the prenatal human brain, paving the way to fully understand the role of these cells in healthy brain development and disease.
LSD-Like Molecules Counter Depression Without the Trip
Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.
Life Expectancy Tool May Improve Quality of Life for Patients With Dementia
A mortality prediction model for older adults with dementia may help physicians determine which treatments to provide while facilitating decision-making for patients and their families.
Landmark Study of Biomarker Data May Enable Better Treatment for Early Onset Dementia
UCSF researchers Adam Staffaroni, PhD, and Adam Boxer, MD, PhD developed models of clinical and biomarker dynamics to determine the temporal sequence of biomarker and clinical changes in f-FTD before disease progression begins.
Dozens of Gut Bacteria Associated with Multiple Sclerosis
Researchers have found significant differences between the gut bacteria profiles of multiple sclerosis (MS) patients and healthy individuals, showing new pathways for potential treatment.
