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Gut Microbes May Influence Multiple Sclerosis Progression
Researchers at UCSF have identified specific gut microbes associated with MS in human patients, showing that these microbes take part in regulating immune responses in mouse models of the disease.
Blunting CRISPR’s ‘Scissors’ Gives New Insight into Autoimmune Disorders
Research team led by University of California scientists has used a modified version of the gene-editing technique CRISPR to find enhancers by prompting them into action.
Gut Feeling for Probiotics Benefits May Be Overstated, UCSF Study Shows
A study headed by UCSF researchers fuels the probiotics debate by finding that there is no clear evidence that a supplement of the “friendly” bacteria strain of lactobacillus prevents eczema.
Gut Viruses Tied to Potentially Deadly Complication of Bone Marrow Transplant
A virus hiding quietly in the gut may trigger the onset of a severe complication known as graft-versus-host disease (GvHD) in patients who receive bone marrow transplants.
Immune-Cell Numbers Predict Response to Combination Immunotherapy in Melanoma
Whether a melanoma patient will better respond to a single immunotherapy drug or two in combination depends on the abundance of certain white blood cells within their tumors, according to a new study.
Brain’s Immune Cells May Drive Overeating and Weight Gain
Immune cells in the brain trigger overeating and weight gain in response to diets rich in fat, according to a new study in mice led by researchers from UCSF and the UW Medical Center.
New Hair Growth Mechanism Discovered
In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells, directly trigger stem cells in the skin to promote healthy hair growth.
Video Imaging Reveals How Immune Cells Sense Danger
How T cells feel out intruders rapidly and reliably enough to nip infections and other threats in the bud has remained a mystery to researchers.
New Polio Virus Evolution Insights Could Lead to Improved Vaccine
UCSF researchers have helped to identify the three evolutionary steps the polio virus used to evolve from harmless vaccine into a regional menace. With the new knowledge, they have developed a new polio vaccine that should be unable to escape and cause outbreaks.
Successful Immunotherapy Requires System-Wide Immune Response
New research has found that successful cancer immunotherapy appears to depend on whether the treatment can trigger a system-wide immune response, rather than just a local response within the tumor itself.
New ‘Immunoprofiler’ Initiative will Advance Drug Discovery, Precision Immunotherapy for Cancer
UC San Francisco scientists have formed an innovative research alliance with three global pharmaceutical companies.
Positive Multiple Sclerosis Clinical Trial Results Support New Treatment Approach
In findings that show the effectiveness of a new strategy for treating multiple sclerosis, researchers are reporting positive results from three large, international, multicenter Phase III clinical trials of the investigational drug ocrelizumab in both relapsing multiple sclerosis and primary progressive multiple sclerosis.
Research Cracks Genetic Driver of Patient’s Rare Immune Disorder
UCSF-led research team identified the rare genetic mutation responsible for a unique case of severe combined immunodeficiency, a deadly immune system disorder also known as “boy in the bubble” disease.