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A new link between meal times and daily changes in the immune system has been identified by UCSF researchers, and has led them to question assumptions about the roles of specific immune cells in infection and allergy.
An antihistamine discovered in the 1950s to treat itching may also prevent seizures in an intractable form of childhood epilepsy, according to researchers at UC San Francisco who tested it in zebrafish bred to mimic the disease.
Researchers have probed deep into the cell’s genome to begin learning the “grammar” that helps determine whether or not a gene gets switched on to make the protein it encodes, advancing efforts to use gene and cell-based therapies to treat disease.
A team of investigators led by UCSF and the Gladstone Institutes has found a way to map an enzyme’s underlying molecular machinery, revealing patterns that could allow them to predict how an enzyme behaves – and what happens when this process disrupted.
An experimental drug designed to block the advance of type 1 diabetes in its earliest stages has proven strikingly effective over two years in about half of the patients who participated in the phase 2 clinical trial, UCSF and Yale University report.
UCSF researchers have found a way to knock down cancers caused by a tumor-driving protein called “myc,” paving the way for patients with myc-driven cancers to enroll in clinical trials for experimental treatments.
The ability to form blood vessels is one of evolution’s crowning achievements. Now, scientists at the Gladstone Institutes have identified the molecular signals that direct the process of committing endothelial cells to become arteries or veins during embryonic development.
Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs lowered the risk of stroke by almost one-third, compared to aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks.
New research conducted at UCSF sheds lights on how fingers and toes are formed in the womb, a finding likely to fundamentally reshape biologists' understanding of how cells communicate to each other during development.