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Giant lizards with superpowered hearts. Hairless rodents that don’t seem to age. Songbirds that babble like human babies. These and other scurrying, soaring, and slithering wonders are teaching scientists how our own bodies work – and how to fix them.
In the new study, UCSF researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.
SARS-CoV-2 uses its distinctive spike to latch onto a receptor called ACE2 on the surface of a human cell. Once there it prompts the human cell to ferry the virus inside. Then, the virus co-opts human enzymes to make copies of itself and spread to other cells.
An international team of researchers studied the three lethal coronaviruses SARS-CoV-2, SARS-CoV-1 and MERS-CoV in order to identify commonly hijacked cellular pathways and detect promising targets for broad coronavirus inhibition.
Some supposedly inert ingredients in common drugs — such as dyes and preservatives — may potentially be biologically active and could lead to unanticipated side effects, according to a preliminary new study by researchers from the UCSF and the Novartis Institutes for BioMedical Research.
UCSF researchers have now determined how the TRPA1 molecule manages to sense such a diverse variety of dangerous chemicals – and do so with enough sensitivity to let you flee before suffering too much tissue damage.
As people around the world try to envision recovery from the COVID-19 pandemic, much attention has been paid to antibody testing as a way to identify people who have developed immunity to the virus. UCSF experts explain how antibody testing works, who it can be most useful for and why we should be cautious.
UCSF is recruiting newly diagnosed COVID-19 patients for a large global clinical trial testing whether the common anti-inflammatory drug colchicine can reduce hospitalization and death caused by the illness.
Though many hopes are hanging on the development of a vaccine or drug that targets the novel coronavirus directly, a UCSF-led team is taking an unconventional approach: target the host – in other words, you.