New CRISPR Technology Offers Unrivaled Control of Epigenetic Inheritance
Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome.
University of California San Francisco
Give to UCSFScientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome.
Cancer starts with mutations in a cell’s DNA, but new UCSF research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which it grows.
A large study of brain MRI scans from 11,679 children between the ages of 9 and 10 reviewed by UC San Francisco neuroradiologists identified potentially life-threatening conditions in 1 in 500
Scientists at UCSF’s Neuroscape brain research center have developed a first-of-its-kind virtual reality video game that can improve memory in healthy, older adults.
Researchers at UCSF have confirmed that a different, long under-studied type of brain cell – astrocytes, named for their star-like shape – can influence how long and how deeply animals sleep.
A new study led by UC San Francisco finds that young adulthood may be the most critical period to practice the healthy lifestyle habits that may protect the brain from cognitive decline decades later.
There is a big, global problem: viruses such as HIV and COVID-19 mutate, but treatments for them don’t.
In a new study, UCSF and Stanford researchers have identified a central switch that appears to control when neural progenitor cells stop multiplying and start differentiating into mature neurons.
UCSF researchers found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.
We turned to UCSF scientists to better understand probiotics and the human microbiome they aim to influence.
A new study of autism risk genes by UCSF and UC Berkeley scientists implicates disruption in prenatal neurogenesis – a process in which specialized “progenitor” cells give rise to new brain cells – in the development of autism spectrum disorders.
A UCSF team has engineered a tiny antibody capable of neutralizing the coronavirus.
Depression is among the most common psychiatric disorders, affecting as many as 264 million people worldwide and leading to hundreds of thousands of deaths per year. But as many as 30 percent of patients do not respond to standard treatments such as medication or psychotherapy.
A team of researchers has identified for the first time the neurons that are among the first victims of Alzheimer’s disease.
UCSF scientists have discovered a new way to control the immune system’s “natural killer” cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.
Patterns of brain activity can be used to forecast seizure risk in epilepsy patients several days in advance, according to a new analysis of data obtained from clinically approved brain implants by neuroscientists at UCSF, the University of Bern and the University of Geneva.
The device, which may be a better illness indicator than a thermometer, could lead to earlier isolation and testing, curbing the spread of infectious diseases.
A group at Gladstone Institutes and UCSF has demonstrated that a large-scale and systematic genetic approach can indeed yield reliable and detailed information on the structure of protein complexes.
Giant lizards with superpowered hearts. Hairless rodents that don’t seem to age. Songbirds that babble like human babies. These and other scurrying, soaring, and slithering wonders are teaching scientists how our own bodies work – and how to fix them.
In the new study, UCSF researchers showed rapid restoration of youthful cognitive abilities in aged mice, accompanied by a rejuvenation of brain and immune cells that could help explain improvements in brain function.
Children with dyslexia who watched emotionally evocative videos showed increased physiological and behavioral responses when compared to children without dyslexia.
Every fall, Matt Jacobson relives his Parkinson’s diagnosis so future pharmacists perceive the patient behind the prescription.
The study adds to a body of evidence indicating that pollution from cars, factories, power plants and forest fires joins established dementia risk factors like smoking and diabetes.
Finding medicines that can kill cancer cells while leaving normal tissue unscathed is a Holy Grail of oncology research.
Researchers found that teens with migraines whose high schools started before 8:30 a.m. experienced close to three more headache days than those with later school start times.
An international research team led by UCSF scientists has shown, for the first time, that gut immune cells travel to the brain during multiple sclerosis flare-ups in patients.
SARS-CoV-2 uses its distinctive spike to latch onto a receptor called ACE2 on the surface of a human cell. Once there it prompts the human cell to ferry the virus inside. Then, the virus co-opts human enzymes to make copies of itself and spread to other cells.
But what is uncertainty? What’s going on in the brain when we feel uncertain? And how might long-term uncertainty experienced by an entire population affect community health?