New Tourette Disorder Genes Come to Light
In DNA sequencing study of TD, UCSF researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition.
University of California San Francisco
Give to UCSFIn DNA sequencing study of TD, UCSF researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition.
UCSF researchers have uncovered 12 new anti-CRISPR genes, some of which can inhibit different CRISPR types and could be critical to future gene-editing therapies.
Genetic mutations in a form of non–small cell lung cancer may drive tumor formation by blurring cells’ perception of key growth signals, according to a new laboratory study published Aug. 31, 2018, in Science.
By creating a tailored drug cocktail that matches the mutations of a brain tumor, a new precision medicine approach may move the needle for children with high-grade gliomas.
In these patients, chronic tissue inflammation causes an over-active protein to introduce mutations across the genome, some of which eventually lead to cancer.
Health professionals should recommend against parents using direct-to-consumer genetic sequencing to diagnose or screen their newborns.
Researchers have identified a new strategy for potentially treating a subset of intractable cancers by decoupling the entire RAS / MAP Kinase signaling pathway from external growth signals.
A decades-old medical mystery has been solved by researchers at UCSF and St. Jude Children’s Research Hospital in Tennessee, who have discovered a pair of inherited genetic mutations underlying a familial blood disorder that sometimes leads to leukemia.
Clinicians and researchers at UCSF Benioff Children’s Hospital Oakland and UCSF are developing tools to combat negative health outcomes from toxic stress.
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
A comprehensive genetic analysis of metastatic prostate cancer has, for the first time, revealed a number of major ways in which abnormal alterations of the genome propel this aggressive form of the disease.
UCSF researchers have identified the sequence of genetic changes that transform benign moles to into malignant skin cancer.
The already famous CRISPR system allows scientists to edit faulty genes by cutting and replacing sections of DNA, but new and improved CRISPR techniques developed at UCSF have expanded CRISPR’s scalpel into a Swiss Army knife.
Sensory Processing Disorder, or SPD, causes some children to find everyday stimuli excruciating. Scientists are finally shedding light on what causes the disorder and what can be done about it.
A so-called “jumping gene” that researchers long considered either genetic junk or a pernicious parasite is actually a critical regulator of the first stages of embryonic development.
Each year, 300,000 infants worldwide are born with sickle cell. UCSF Benioff Children’s Hospitals are at the the leading edge of advancements to cure sickle cell disease.
The journey from discovering and developing effective, precise medications to using them correctly and safely in patients is hardly fast and easy. Nor is it a straight shot. Scientists in the UCSF School of Pharmacy are challenging the status quo every step of the way.
Researchers have demonstrated the ability to program groups of individual cells to self-organize into multi-layered structures reminiscent of simple organisms or the first stages of embryonic development.
UCSF researchers have safely transplanted a woman’s stem cells into her growing fetus, leading to the live birth of an infant with a normally fatal fetal condition.
In just the last few years, Zachary Knight’s research has upended textbook theories of hunger and thirst.
Every day, on average, 10 new genetic tests become commercially available to help doctors and patients make more informed decisions about health care. Yet few doctors know how to navigate the tens of thousands of tests that populate the genetic testing marketplace, which prevents patients from benefiting from them.
Esteban Burchard, who arrived at UCSF in 1998, marks the 20th year of his asthma project in May. His lab, which he named the UCSF Asthma Collaboratory, has delved deep into the genetic basis of asthma and of drug response in the disease.
By studying a rare liver disease called Alagille syndrome, scientists from UC San Francisco and Cincinnati Children’s Hospital Medical Center have discovered the mechanism behind an unusual form of tissue regeneration that may someday reduce the need for expensive and difficult-to-obtain organ transplants.
Data from clinical studies of gene therapy in patients with transfusion-dependent Beta-Thalassemia show majority of patients are transfusion-free.
New study could make it much easier for physicians to use the genetic profile of a patient’s tumor to pick the chemotherapy treatment with the fewest side effects and best chance of success.
In a move that underscores the increasingly important role of genomics in medicine, UCSF has appointed Aleksandar Rajkovic, MD, PhD, as the first Chief Genomics Officer of UCSF Health. His appointment, which follows a national search, is effective May 1.
A new study finds that a common cancer-causing mutation in a GTPase called Gαs subverts the model for this type of growth switch in cancer.
The largest analysis to date of genetic data in ALS has identified two previously unrecognized genetic risks that are significantly associated with the disease.
Ata's appearance can most likely be explained by a handful of rare genetic mutations—some already known, others newly discovered—that are linked to dwarfism and other bone and growth disorders.
A new study in mice reveals how a gene mutation seen in human short-sleepers may allow them to survive and thrive on just a few hours of sleep.