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  • Research

New kidney transplant drug effective in humans, UCSF study finds

UCSF nephrologist Flavio Vincenti, MD, is the lead author of a paper in the March 2010 issue of the <i>American Journal of Transplantation</i> that reports results from a Phase III clinical trial for a new drug that selectively blocks immune suppression for kidney transplants. The drug, belatacept, is given to kidney-transplant recipients to prevent the immune system from rejecting the new organ. Vincenti and his co-investigators found that belatacept may be as effective as the commonly used anti-rejection drug cyclosporine, but with fewer side effects and superior kidney function after 12 months.

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  • Research

NIH stem cell guidelines should be modified, UCSF team reports

A UCSF team, led by bioethicist Bernard Lo, MD, recommends that the National Institutes of Health ethics guidelines for embryonic stem cell research be modified to better protect the rights of individuals donating egg or sperm to patients undergoing in vitro fertilization.

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  • Research

Killing in Iraq combat linked with PTSD, alcohol abuse, other problems

Among soldiers who served in Iraq, the act of taking a life in combat was a significant predictor of post-traumatic stress disorder, alcohol abuse, hostility and anger, and relationship problems, according to a study led by a psychologist at the San Francisco VA Medical Center.

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  • Research

Most Iraq and Afghanistan veterans with PTSD did not get enough care, study shows

Between 2002 and 2008, fewer than 10 percent of U.S. veterans of the wars in Iraq and Afghanistan who were newly diagnosed with post-traumatic stress disorder received the recommended course of care for their condition at VA health facilities, according to a study by researchers at the San Francisco VA Medical Center and UCSF.

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  • Research

Neuroimaging Study May Pave Way for Effective Alzheimer's Treatments

Scientists have determined that a new instrument known as PIB-PET is effective in detecting deposits of amyloid-beta protein plaques in the brains of living people, and that these deposits are predictive of who will develop Alzheimer&#8217;s disease.

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  • Research

Gene family found to play key role in early stages of development

Scientists have identified a gene family that plays a key role in one of the earliest stages of development in which an embryo distinguishes its left side from the right and determines how organs should be positioned within the body. The finding in mice likely will lead to a better understanding of how certain birth defects occur in humans.

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  • Research

Study Indicates Link Between Second-Hand Smoke, Narrowed Neck Artery, and Dementia

Non-smokers with both long-term exposure to second-hand cigarette smoke and narrowing of the artery that brings blood to the brain had three times the risk of developing dementia than people without either of those risk factors, according to a study led by a researcher at the San Francisco VA Medical Center.

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  • Research

Even a small dietary reduction in salt could mean fewer heart attacks, strokes and deaths

Reducing salt in the American diet by as little as one-half teaspoon (or three grams) per day could prevent nearly 100,000 heart attacks and 92,000 deaths each year, according to a new study. Such benefits are on par with the benefits from reductions in smoking and could save the United States about $24 billion in healthcare costs, the researchers add.

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  • Research

Periodic paralysis study reveals gene causing disorder

Scientists have identified a gene underlying a disease that causes temporary paralysis of skeletal muscle. The finding, they say, illustrates how investigations of rare genetic diseases can drive insights into more common ones.

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