The Road to Rejuvenation
Fortified stem cells. Enhanced memory. A longevity hormone. UCSF researchers are finding out whether we can cancel – or at least delay – old age.
University of California San Francisco
Give to UCSFFortified stem cells. Enhanced memory. A longevity hormone. UCSF researchers are finding out whether we can cancel – or at least delay – old age.
A collaboration is between two biomedical researchers bridges the laboratory and clinic to advance the science of itch, allergy and asthma.
Leanne Jones, PhD, is at the forefront of studying how stem cells are influenced by their surrounding environment and directed to differentiate into one type of cell or another – research that’s critical for stem cell therapies to be successful.
Faranak Fattahi’s lab is a national leader in growing stem cells to model peripheral nerves, focusing on gastrointestinal diseases.
Vissers’ work on RNA tags helped found the field of epitranscriptomics, the study of how chemical marks on RNA, rather than their sequence alone, dictate the function of the molecules.
Sneddon is trying to coax stem cells into reliably developing functional beta cells that can then be transplanted into patients with diabetes so that they can produce their own insulin.
Scientists at UCSF have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases in mice.
Cronutt was one sick sea lion before undergoing a groundbreaking surgery last fall. Today he's seizure-free and doing well.
UCSF scientists have discovered a new way to control the immune system’s “natural killer” cells, a finding with implications for novel cell therapies and tissue implants that can evade immune rejection.
Giant lizards with superpowered hearts. Hairless rodents that don’t seem to age. Songbirds that babble like human babies. These and other scurrying, soaring, and slithering wonders are teaching scientists how our own bodies work – and how to fix them.
For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways. To create complex tissues and organs –
UCSF researchers are finding new clues to how neuropsychiatric disorders unfold by focusing on the role of a little-studied form of DNA in early brain development.
A new study highlights the potential of a novel, inhalable regenerative therapy for the treatment of idiopathic pulmonary fibrosis.
Why are more men than women dying of COVID-19? Scientist Faranak Fattahi, PhD, has found a clue.
UCSF researchers are taking a closer look at COVID-19’s dizzying array of symptoms to get at the disease’s root causes.
Administering stem cell or enzyme therapy in utero may be a path to alleviating some congenital diseases that often result in losing a pregnancy, according to a new study in mice by UCSF researchers. They showed that stem cells can enter the fetal brain during prenatal development and make up for cells that fail to make an essential protein.
Widely used organoid models fail to replicate even basic features of brain development and organization, much less the complex circuitry needed to model complex brain diseases or normal cognition.
UCSF postdoctoral researcher for the first time succeeded in keeping a diverse array of glioblastomas alive in the lab using brain organoids
Advances in medicine and public health have dramatically extended the lifespan of hearts, lungs, and other vital organs. But for women, the ovaries remain a stubborn exception. That may soon change, says fertility expert Marcelle Cedars.
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We asked Arnold Kriegstein, MD, PhD, director of the UCSF Developmental & Stem Cell Biology Program, about for-profit stem cell clinics and what’s real and what’s not in stem cell medicine.
International team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease, a rare genetic condition affecting boys that can be fatal before 10 years of age.
Study shows that the adult-to-iPSC conversion process can mutate DNA found in mitochondria, causing mice and humans to reject iPSCs, and stem cell transplants more generally.
In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.
Brain damage associated with MS specifically targets a common class of brain cells called projection neurons
A new study suggests that the human brain may maintain reserves of immature neurons throughout life, using these “Peter Pan” cells in a similar manner to the neurogenesis seen in other species
Changes in gene activity in specific brain cells are associated with the severity of autism in children and young adults with the disorder.
Newly discovered radiation-resistant stem cells are normally rare and inactive (left), but they take on a major role in muscle repair when regular stem cells are damaged by radiation (right). Credit: