University of California San Francisco
Give to UCSFResearchers at UC San Francisco have successfully developed a “speech neuroprosthesis” that has enabled a man with severe paralysis to communicate in sentences, translating signals from his brain to the vocal tract directly into words that appear as text on a screen.
Children with a devastating genetic disorder characterized by severe motor disability and developmental delay have experienced sometimes dramatic improvements in a gene therapy trial launched at UCSF Benioff Children’s Hospitals.
Scientists at UCSF have shown that gene-edited cellular therapeutics can be used to successfully treat cardiovascular and pulmonary diseases in mice.
Taking a page from computer engineers, biologists are trying their hands at programming cells – by building DNA circuits to guide their protein-making machinery and behavior.
Plenty of probiotic yogurts, pickles and kombuchas claim to boost our digestive health with armies of microbes, but some scientists have more ambitious therapeutic plans for the “bugs” that colonize us. They hope to leverage these microbes as living therapeutics for a range of health conditions, including ulcerative colitis, multiple sclerosis, eczema and asthma.
T cells – immune cells that patrol our bodies in search of trouble – have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells
The B.1.1.7 coronavirus variant—also known as Alpha—may be more infectious because it contains mutations that make it better adapted to foil the innate immune system, at least for long enough to allow the virus to replicate and potentially find new hosts, according to a new study.
An elderly man had symptoms no one could explain – until Amy Berger, MD, PhD, and her team investigated.
Cronutt was one sick sea lion before undergoing a groundbreaking surgery last fall. Today he's seizure-free and doing well.
Leading scientists share some of the tools and strategies that could help us better confront and contain future outbreaks.
Insomnia is miserable, and lost sleep can harm our health. Now, researchers are seeing the promise of solutions in our genes.
Hidden autoimmunity may explain how the coronavirus wreaks such widespread and unpredictable harm.
UCSF alum and Moderna president Stephen Hoge, MD '03, shares what it was like to design a desperately needed vaccine in record time.
Cognitive behaviorial therapy for insomnia, the gold-standard intervention, also suggests benefits for well-being.
The viruses that cause polio and COVID-19 mutate, but treatments for the diseases don’t. For over 20 years, UCSF and Gladstone Institutes scientist Leor Weinberger, PhD, has been thinking of ways to make vaccines work more efficiently by being adaptive, rather than static.
UCSF researchers wanted to see if simple tweaks, like avoiding nighttime interruptions to promote sleep, nixing certain prescription drugs, and promoting exercise and social engagement, could decrease delirium in hospitalized older adults.
Scientists now have shown that the weakening of an astronaut’s immune system during space travel is likely due in part to abnormal activation of immune cells called T regulator cells.
Sophie Dumont, winner of the 2021 Byers Award for Basic Science, focuses on finding out how, as well whether therapeutic targets exist to ensure equal – and healthy – division of chromosomes.
UCSF researchers have created a CRISPR technique to study how turning on or off single genes affects the function of different cell types and how these changes play a role in disease.
Researchers at UCSF have observed a new feature of neural activity in the hippocampus – the brain’s memory hub – that may explain how this vital brain region combines a diverse range of inputs into a multi-layered memories that can later be recalled.
New research by UCSF scientists shows retinal scans can detect key changes in blood vessels that may provide an early sign of Alzheimer’s disease.
UCSF researchers have figured out precisely what receptor tyrosine kinases are, how they form and their role in cancer.
Scientists at UCSF are learning how immune cells naturally clear the body of defunct – or senescent – cells that contribute to aging and many chronic diseases
Pioneering neural recordings in patients with Parkinson’s disease by UCSF scientists are providing the groundwork for personalized brain stimulation to treat Parkinson’s and other neurological disorders.
A team at UCSF, in collaboration with colleagues at Stanford University, has unearthed the regulatory DNA sequences of our archaic human ancestors in a discovery that sheds light on how we diverged from them 500,000 years ago.
Games and supplements claim to strengthen memory and cognition. Should you buy them?
Researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.