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Displaying 2521 - 2550 of 3098
  • New research strategy for understanding drug resistance in leukemia

    UCSF researchers have developed a new approach to identify specific genes that influence how cancer cells respond to drugs and how they become resistant. This strategy, which involves producing diverse genetic mutations that result in leukemia and associating specific mutations with treatment outcomes, will enable researchers to better understand how drug resistance occurs in leukemia and other cancers, and has important long-term implications for the development of more effective therapies.

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  • Study reveals benefit of adult stem cells for acute lung injury

    UCSF scientists have demonstrated that adult human mesenchymal stem cells reverse the effects of injury in a novel human lung preparation in the lab. The finding, they say, could lead to the development of stem cell therapies for patients with acute lung injury and acute respiratory distress syndrome, conditions that presently have a high rate of mortality and no pharmacological treatments.

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  • Some skin cancer may be mediated by primary cilia activity

    Tiny, solitary spikes that stick out of nearly every cell in the body play a central role in a type of skin cancer, new research has found. The discovery in mice shows that the microscopic structures known as primary cilia can either suppress or promote this skin cancer, depending on the mutation triggering the disease.

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  • UCSF researchers identify two key pathways in adaptive response

    UCSF researchers have identified the two key circuits that control a cell’s ability to adapt to changes in its environment, a finding that could have applications ranging from diabetes and autoimmune research to targeted drug development for complex diseases.

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  • UCSF and Hill Physicians form new health care option for San Francisco

    UCSF Medical Group and Hill Physicians Medical Group have formed a new affiliation to provide access to high-quality primary and specialty health services for HMO members whose primary care provider is based in San Francisco. Hill Physicians is the largest independent physician association in Northern California.

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  • UCSF primary care expert participates in White House health policy roundtable

    Kevin Grumbach, MD, chair of the UCSF Department of Family and Community Medicine, participated in a health policy roundtable at the White House on August 10. The forum was chaired by Nancy Ann DeParle, director of the White House Office of Health Reform, and addressed primary care and medical home innovations.

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  • UCSF statement regarding CNA demonstration on 8-05-09

    Allegations by CNA that a UCSF nurse was terminated because of comments made about unsafe patient care practices related to H1N1 <u>are unfounded</u>. This individual was a patient care nurse who was still in her probationary period, and she was released due to performance factors that occurred during this period. CNA has filed a grievance on behalf of this individual, and UCSF is proceeding through appropriate channels to address the situation.

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  • UCSF researchers identify new drug target for Kaposi's Sarcoma

    UCSF researchers have identified a new potential drug target for the herpes virus that causes Kaposi&#8217;s sarcoma, re-opening the possibility of using the class of drugs called protease inhibitors against the full herpes family of viruses, which for 20 years has been deemed too difficult to attain.

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  • San Francisco supervisors approve helipad at UCSF Mission Bay Hospital

    The San Francisco Board of Supervisors today (July 28, 2009) approved a resolution that allows for the operation of a helipad at the new UCSF Medical Center at Mission Bay, a state-of-the-art hospital complex for children, women and cancer patients scheduled to open in 2014. The resolution passed unanimously, by a vote of 11 to 0.

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  • UCSF launches medication consultation service in Fresno

    The UCSF School of Pharmacy has launched a Medication Management Service in Fresno to address the urgent need among California Central Valley residents and their health care providers for assistance in managing their prescriptions.

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  • Mental health problems seen in more than one third of first-time VA patients who served in Iraq or Afghanistan

    Among 289,328 veterans of Iraq or Afghanistan who used the Department of Veterans Affairs medical system for the first time between April 1, 2002 and April 1, 2008, 37 percent received a diagnosis of a mental health problem, according to a study of national VA data conducted by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

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  • UCSF researchers help crack parasite genome, identify drug leads

    Two UCSF research papers this week are marking major breakthroughs in the effort to tackle schistosomiasis (bilharzia), a tropical disease that infects more than 200 million people worldwide and causes long-term debilitating illness and occasional paralysis or death.

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  • Maintaining or increasing physical activity slows cognitive decline in elders

    Elders who maintained or increased their level of physical activity showed significantly less cognitive decline over seven years than those who were not active or whose activity levels declined during that time, according to a study led by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

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  • PTSD Linked with Almost Double Dementia Risk, Study Finds

    Older veterans with post-traumatic stress disorder were almost twice as likely to develop dementia as veterans without PTSD in a study of more than 180,000 veterans led by researchers at the San Francisco VA Medical Center and the University of California, San Francisco.

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  • Stem cells' "suspended" state preserved by key step, scientists report

    Scientists have identified a gene that is essential for embryonic stem cells to maintain their all-purpose, pluripotent state. Exploiting the finding may lead to a greater understanding of how cells acquire their specialized states and provide a strategy to efficientlyreprogram mature cells back into the pluripotent state, an elusive step in stem cell research but one crucial to a range of potential clinical treatments.

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  • MS study offers theory for why repair of brain's wiring fails

    Scientists have uncovered new evidence suggesting that damage to nerve cells in people with multiple sclerosis accumulates because the body&#8217;s natural mechanism for repair of the nerve coating called &#8220;myelin&#8221; stalls out.

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  • Early heart attack therapy with bone marrow extract improves cardiac function

    A UCSF study for the treatment of heart failure after heart attack found that the extract derived from bone marrow cells is as effective as therapy using bone marrow stem cells for improving cardiac function, decreasing the formation of scar tissue and improving cardiac pumping capacity after heart attack.

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