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CryoEM Study Captures Opioid Signaling in the Act

Scientists have used ultra-high-resolution cryo–electron microscopy to capture the most detailed portrait ever of an opioid drug triggering the biochemical signaling cascade that gives it its power.

Life After the Diagnosis

This new book by international palliative care expert and UCSF physician Steven Pantilat, MD ’89, serves as a guide for those who don’t know where to start at a difficult time. Pantilat makes sense of what doctors may say, what they actually mean, and how to get the information you need to make the best medical decisions.

Grad Slam: “Don’t Go Breaking My Heart … Again”

This UC San Francisco competition challenges PhD students to use engaging “nonspecialist” language to describe their intricate research – in three minutes or less. Bioengineering student Yiqi Cao won the top prize this year for her talk about how to improve stents to reduce scar tissue. “Grad Slam was an incredible opportunity to challenge myself,” Cao says. “It’s definitely not easy to distill … many years of research down to a meaningful three minutes.”

NPR’s Nerdette: “I Have A Rare Genetic Disease. CRISPR Might Fix It.”

As a kindergartener, Nerdette co-host Greta Johnsen was diagnosed with an eye condition that is among the best diseases for experimenting with the gene editing tool CRISPR. This episode follows Greta, her father, and UCSF geneticist and Gladstone Institutes investigator Bruce Conklin, MD, as he tries to develop the perfect CRISPR system to remove the faulty DNA from Johnsen’s eye cells.