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Administering stem cell or enzyme therapy in utero may be a path to alleviating some congenital diseases that often result in losing a pregnancy, according to a new study in mice by UCSF researchers. They showed that stem cells can enter the fetal brain during prenatal development and make up for cells that fail to make an essential protein.
Widely used organoid models fail to replicate even basic features of brain development and organization, much less the complex circuitry needed to model complex brain diseases or normal cognition.
UCSF postdoctoral researcher for the first time succeeded in keeping a diverse array of glioblastomas alive in the lab using brain organoids
Advances in medicine and public health have dramatically extended the lifespan of hearts, lungs, and other vital organs. But for women, the ovaries remain a stubborn exception. That may soon change, says fertility expert Marcelle Cedars.
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We asked Arnold Kriegstein, MD, PhD, director of the UCSF Developmental & Stem Cell Biology Program, about for-profit stem cell clinics and what’s real and what’s not in stem cell medicine.
International team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease, a rare genetic condition affecting boys that can be fatal before 10 years of age.
Study shows that the adult-to-iPSC conversion process can mutate DNA found in mitochondria, causing mice and humans to reject iPSCs, and stem cell transplants more generally.
In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.
Brain damage associated with MS specifically targets a common class of brain cells called projection neurons
A new study suggests that the human brain may maintain reserves of immature neurons throughout life, using these “Peter Pan” cells in a similar manner to the neurogenesis seen in other species
Changes in gene activity in specific brain cells are associated with the severity of autism in children and young adults with the disorder.
Newly discovered radiation-resistant stem cells are normally rare and inactive (left), but they take on a major role in muscle repair when regular stem cells are damaged by radiation (right). Credit:
