Looking Beyond DNA to See Cancer with New Clarity
Researchers at UCSF and UC San Diego have mapped out how hundreds of mutations involved in two types of cancer affect the activity of proteins that are the ultimate actors behind the disease.
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An Estrogen Receptor that Promotes Cancer also Causes Drug Resistance
Researchers at UCSF have gained insight into how cancer cells proliferate despite a myriad of stresses.
Beyond CAR-T: New Frontiers in Living Cell Therapies
Taking a page from computer engineers, biologists are trying their hands at programming cells – by building DNA circuits to guide their protein-making machinery and behavior.
Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More
T cells – immune cells that patrol our bodies in search of trouble – have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells
Sophie Dumont Delivers 2021 Byers Award Lecture: ‘Who Conducts the Symphony of Cell Division?’
Sophie Dumont, winner of the 2021 Byers Award for Basic Science, focuses on finding out how, as well whether therapeutic targets exist to ensure equal – and healthy – division of chromosomes.
Spread of Breast Cancer Linked to Newly Discovered RNA Splicing Mechanism
What kills most people who die from cancer is not the initial tumor. It’s the intolerable disease burden on the body that arises when tumor cells continually expand their numbers after spreading to different organs.
Novel Structure Found in Tumor Cells May Open Door to New Kinds of Cancer Therapies
UCSF researchers have figured out precisely what receptor tyrosine kinases are, how they form and their role in cancer.
Cancer Patients Lonely and Depressed During COVID-19 Pandemic
Loneliness and social isolation have been significant problems for the general population during the COVID-19 pandemic, but for cancer patients these issues were particularly acute, likely due to isolation and social distancing, according to a new UCSF study.
Smart Cell Therapies for Solid Cancers Ready to Move Toward Clinical Trials
Researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.
First of Its Kind Study Links Wildfire Smoke to Skin Disease
A new study suggests that the dangers posed by wildfire smoke may also extend to the largest organ in the human body, and our first line of defense against outside threat: the skin.
Deaths Rising in Workers Using Methylene Chloride Paint Strippers
The study is the first comprehensive review of fatalities linked to the deadly chemical in the United States and identified more deaths than previously reported.
Pancreatic Cancer Cells Hijack Muscle Protein to Beef Up Their Metabolism
Cancer starts with mutations in a cell’s DNA, but new UCSF research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which it grows.
Store Fat or Burn It? Targeting a Single Protein Flips the Switch
UCSF researchers found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.
Podcast: How a Fascination with Saliva Helped Solve a Health Crisis
Tissue biologist Sarah Knox has long been fascinated with saliva. Just when she begins to doubt whether her singular passion will lead to real-world impact, an old family friend reaches out to her with a problem only she may be able to solve.
