UC San Francisco-Led Team Uncovers Potential Risks to Cardiac Condition Previously Thought Benign
A common test that records the heart’s electrical activity could predict potentially serious cardiovascular illness, according to a UC San Francisco-led study.
Gregory Marcus, MD
A cardiac condition called left anterior fascicular block (LAFB), in which scarring occurs in a section of the left ventricle, may not be as benign as currently thought and could increase the likelihood of heart failure, sudden cardiac death or atrial fibrillation.
In a study published on April 17 in the Journal of the American Medical Association (JAMA), UCSF researchers and their colleagues at Wake Forest School of Medicine and the University of Washington, Seattle, analyzed data on 1,664 people over the age of 65 who were medically followed for 16 years.
The researchers selected those who had no evidence of cardiovascular disease from the National Institutes of Health-sponsored Cardiovascular Health Study. People with heart failure, high blood pressure or diabetes, or who had heart attacks, were excluded from the study sample.
“We then compared those with LAFB to those with a normal electrocardiogram (EKG),” said senior author Gregory Marcus, MD, an electrophysiologist with the UCSF Division of Cardiology and an associate professor in residence with the UCSF School of Medicine. “We found that those who had LAFB indeed had a higher risk of atrial fibrillation, congestive heart failure and death.”
After adjusting for other potential confounding variables, LAFB posed a 57 percent greater risk for sudden cardiac death, an 89 percent greater risk for atrial fibrillation, and a 143 percent greater risk for heart failure.
LAFB is a blockage of one of the electrical branches that delivers electrical signals to a part of the left ventricle, one of two chambers in the heart. Small studies suggest it is associated with fibrosis or scarring of the left ventricle, but the clinical ramifications of this have not been previously studied. It is unknown how many people LAFD affects.
“We now have come to realize that important cardiovascular diseases like atrial fibrillation, heart failure and maybe sudden cardiac death, are related to fibrosis of the left side of the heart,” said Marcus, who sees cardiology patients at the UCSF Medical Center. “So we sought to test the hypothesis that LAFB, even in those people who are otherwise healthy, might be a readily available marker that any doctor can see on an EKG, of a propensity to left-heart fibrosis. And it therefore might predict those at risk for atrial fibrillation, heart failure and death.”
The top EKG shows a reading of a person with a healthy heart. The bottom EKG shows a reading of a person with left anterior fascicular block (LAFB), previously thought to be benign but found by a UCSF-led team to potentially signal a serious heart condition.
There currently is no treatment for people with LAFB. However, this new finding potentially could open up a new area of research in cardiology, according to Marcus.
“Currently there is a therapy for people with heart failure and a left bundle branch block using a special pacemaker called a biventricular pacemaker or cardiac resynchronization therapy,” Marcus said. “So one question we have to explore is whether people with LAFB and heart failure, for example, might benefit from a specialized pacemaker.”
Patients also can reduce their overall cardiovascular risk with lifestyle modifications, such as choosing a healthy diet, exercising regularly and eliminating tobacco products.
“This study may suggest that LAFB, even in the absence of known high blood pressure or diabetes, should be thought of as a cardiovascular risk factor,” Marcus said. “Those patients with LAFB perhaps should be considered the same as someone with an established cardiovascular risk factors.”
Co-authors include Mala Mandyam of the UCSF Division of Cardiology, Electrophysiology Section; Eric Vittinghoff, PhD, of the UCSF Department of Epidemiology and Biostatistics; Elsayed Z. Soliman, MD, of the Wake Forest School of Medicine; and Susan R. Heckbert, MD, PhD, of the University of Washington, Seattle.
This study was supported by the National Center for Research Resources, the National Center for Advancing Translational Sciences, and the Office of the Director, National Institutes of Health, through grant TL1 RR024129 to UCSF’s Clinical and Translational Science Institute (CTSI). This research was also supported by contracts HHSN268201200036C, N01HC85239, N01HC55222, N01HC85079, N01HC85080, N01HC85081, N01HC85082, N01HC85083, N01HC85086, and grants HL080295 and HL068986 from the National Heart, Lung, and Blood Institute, with additional contributions from the National Institute of Neurological Disorders and Stroke. Additional support was provided by grant AG023629 from the National Institute on Aging and the Joseph Drown Foundation.
Researchers reported no conflicts of interest to disclose.