The Gladstone Institute of Cardiovascular Disease is hosting a symposium titled "Cardiovascular Disease: The Road to Discovery" on Tuesday, March 7.
The event features six National Academy of Science members, including
Nobel Laureate Michael S. Brown, MD. Brown, a professor of molecular genetics and internal medicine at the University of Texas Southwestern Medical Center in Dallas, will discuss the long-standing ties between Gladstone and his own institution in a talk titled "ApoE/Gladstone and LDL Receptor/Dallas -- 30 Years of High Affinity."
The event is scheduled from 1 to 5:15 p.m. in the Mahley Auditorium at the Gladstone Institutes' Mission Bay facility.
In addition to Brown, this forum brings together distinguished researchers in a wide spectrum of cardiovascular disciplines discussing the most promising areas of discovery and therapeutic intervention. Speakers include:
• Eric N. Olson, PhD, professor and chair, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, will discuss "Genetic Control of Heart Development and Disease."
• Christine Seidman, MD, professor, Departments of Genetics and Medicine, Harvard Medical School, Boston, will give a talk titled "TBX5 & NKX2.5: Partners in Crime."
• Andrew R. Marks, MD, professor and chair, Department of Physiology and Cellular Biophysics, Columbia University College of Physicians & Surgeons, New York, will cover "Mechanisms and Novel Therapies for Heart Failure and Sudden Cardiac Death."
• Jan L. Breslow, MD, professor, Laboratory of Biochemical Genetics and Metabolism, The Rockefeller University, New York, will discuss "Genetics of Atherosclerosis: Studies in Humans, Remote Islands and Mice."
• Gladstone Institutes President
Robert W. Mahley, MD, PhD, will provide an overview of "Apolipoprotein E: From Atherosclerosis to Alzheimer's Disease."
Brown and his long-time colleague, Joseph L. Goldstein, MD, together discovered the low density lipoprotein (LDL) receptor, which controls the level of cholesterol in blood and in cells. Their work laid the theoretical groundwork for the development of statins, which block cholesterol synthesis, increase LDL receptors, lower blood cholesterol and prevent heart attacks. Brown and Goldstein have received many awards for their work, including the US National Medal of Science and the Nobel Prize for Medicine or Physiology. For more than three decades, they have worked closely with Mahley, who discovered apoE, the ligand for the LDL receptor.
"We're honored that such an august group of world-renowned researchers has chosen to share knowledge and insights with the Gladstone and UCSF community," explains GICD Director Deepak Srivastava, MD. "This promises to be an exciting afternoon, filled with new information on the very latest trends in cardiovascular research."
This special event, organized by Srivastava, is being held in recognition of Mahley's 26 years of service as the founding director of GICD. Mahley, president of the Gladstone Institutes since its founding in 1979, concurrently served as GICD director until Srivastava came on board last year.
For more information about the symposium, call 415/734-2716.
Source: John Watson
Links:
Gladstone Institute of Cardiovascular Disease
