Cancer Researchers ID ‘Achilles Heel’ of Drug-Resistant Tumors
UCSF scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies.
University of California San Francisco
Give to UCSFUCSF scientists have figured out why some lung cancers become drug-resistant after initially responding to targeted therapies.
UCSF researchers have devised a CRISPR-based system called SLICE, which will allow scientists to rapidly assess the function of each and every gene in “primary” immune cells.
Genetics may predispose some people to both Alzheimer’s disease and high levels of blood lipids such as cholesterol, a common feature of cardiovascular disease.
To develop novel therapies to treat specific subtypes of COPD, and potentially even to reverse some of the symptoms, scientists at UCSF are taking a precision medicine approach to the disease.
UCSF demonstrates that cancer is a clever engineer, capable of constructing entirely new disease-promoting networks out of raw materials readily available in the cell.
Almost half of the nearly 10 million patients with active tuberculosis each year could potentially be cured with significantly shorter treatments than current guidelines recommend.
Seven UCSF research subject areas were ranked in the top 10 globally by US News & World Report.
Scientists began searching for ways to edit genomes in the 1960s. It would not prove easy.
The ascendancy of CRISPR systems raises a grand hope: If these tools can illuminate the causes of disease in the laboratory, why not bring them into the clinic to treat patients?
UCSF researchers discovered a gene that plays an essential role in noise-induced deafness.
A new blood test for children with brain tumors offers a safer approach than surgical biopsies and may allow doctors to measure the effectiveness of treatment even before changes are identified on scans.
Scientists at UCSF have assembled a searchable database of normal human immunity that researchers can now use as an instant comparison group in studies of the immune system and immune dysfunction.
In a new study discovered that variants at a single site on Chromosome 6 are associated with a significantly higher risk of developing erectile dysfunction.
Nearly all studies of telomere genetics have been performed in adult populations of European or Asian ancestry, meaning that studies aiming to understand how early environmental exposures impact telomere length across different ethnic groups can’t easily assess the role of natural variations in telomere biology.
In DNA sequencing study of TD, UCSF researchers and their collaborators have unearthed new data suggesting a potential role for disruptions in cell polarity in the development of this condition.
UCSF researchers have discovered how a mutation in a gene regulator called the TERT promoter confers “immortality” on tumor cells, enabling the unchecked cell division that powers their aggressive growth.
A new spinal cord injury protocol, based on research by UCSF scientists, is a mixture of revised evaluations and new treatments to personalize care. It has spurred quicker recoveries for patients.
UCSF researchers have uncovered 12 new anti-CRISPR genes, some of which can inhibit different CRISPR types and could be critical to future gene-editing therapies.
Genetic mutations in a form of non–small cell lung cancer may drive tumor formation by blurring cells’ perception of key growth signals, according to a new laboratory study published Aug. 31, 2018, in Science.
By creating a tailored drug cocktail that matches the mutations of a brain tumor, a new precision medicine approach may move the needle for children with high-grade gliomas.
UCSF researchers found that 58 percent of women who resided in a nursing home for more than 90 days before breast cancer surgery experienced significant functional decline one year after surgery.
In these patients, chronic tissue inflammation causes an over-active protein to introduce mutations across the genome, some of which eventually lead to cancer.
Health professionals should recommend against parents using direct-to-consumer genetic sequencing to diagnose or screen their newborns.
Researchers have identified a new strategy for potentially treating a subset of intractable cancers by decoupling the entire RAS / MAP Kinase signaling pathway from external growth signals.
A new UC San Francisco study has discovered a key biological difference in how people of European and Chinese descent put on weight — a finding that could help explain why Asians often develop type 2 diabetes at a much lower body weight than Caucasians.
A decades-old medical mystery has been solved by researchers at UCSF and St. Jude Children’s Research Hospital in Tennessee, who have discovered a pair of inherited genetic mutations underlying a familial blood disorder that sometimes leads to leukemia.
Clinicians and researchers at UCSF Benioff Children’s Hospital Oakland and UCSF are developing tools to combat negative health outcomes from toxic stress.
UCSF scientists have used a high-throughput CRISPR-based technique to rapidly map the functions of nearly 500 genes in human cells, many of them never before studied in detail.
A comprehensive genetic analysis of metastatic prostate cancer has, for the first time, revealed a number of major ways in which abnormal alterations of the genome propel this aggressive form of the disease.
In an achievement that has significant implications for research, medicine, and industry, UCSF scientists have genetically reprogrammed human immune cells without using viruses to insert DNA