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LSD-Like Molecules Counter Depression Without the Trip

Scientists have designed compounds that hit the same key receptor that LSD activates without causing hallucinations. A single dose produced powerful antidepressant and antianxiety effects in mice that lasted up to two weeks.

3D computer model of the 5HT2a receptor

Older Homeless People Are At Great Risk of Dying

The study, funded by the National Institute on Aging, recruited people who were 50 and older and homeless, and followed them for a median of 4.5 years. By interviewing people every six months about their health and housing status, researchers were able to examine how things like regaining housing, using drugs, and having various chronic conditions, such as diabetes, affected their risk of dying.

A tent of an unhoused person is set up next to three garbage bins behind a building

Half of Moms of Kids with Autism Have High Depressive Symptoms

About 50% of all mothers of children with autism spectrum disorder (ASD) had elevated levels of depressive symptoms over 18 months, while rates were much lower (6% to 13.6%) for mothers with neurotypical children in the same period, UCSF researchers report in a new study.

Illustration of a person's sillhouette with clouds in the brain area, suggesting depression

Eye Movements in REM Sleep Mimic Gazes in the Dream World

When our eyes move during REM sleep, we’re gazing at things in the dream world our brains have created, according to a new study by UCSF researchers. The findings shed light not only into how we dream, but also into how our imaginations work.

Closeup of an elderly man with eyes closed

Routine Depression Screening May Capture Underdiagnosed Patient Populations

According to a new UCSF study, screening for depression at the primary care level could dramatically increase the likelihood of treatment for those who are traditionally undertreated — racial and ethnic minority individuals, older adults, those with limited English proficiency and men.