Treating Disease Before Birth
Stem cell transplantation may hold the promise to treating many diseases before birth such as sickle cell anemia and muscular dystrophy. But first, researchers need to overcome many barriers, including rejection of stem cell transplants by the fetus. MacKenzie’s lab recently discovered that mothers’ T cells are responsible for rejecting the grafts and that this rejection may be avoided by using stem cells from the mother.
Tippi MacKenzie, MD
UCSF Division of Pediatric Surgery
Funding for MacKenzie’s research is provided by the American College of Surgeons, American Pediatric Surgery Association, American Surgical Association, California Institute for Regenerative Medicine, March of Dimes and the National Institutes of Health.