Recent articles by Anne Holden
Scientists Identify Molecular Switch that Kick-Starts Formation of Arteries
July 03, 2013The ability to form blood vessels is one of evolution’s crowning achievements. Now, scientists at the Gladstone Institutes have identified the molecular signals that direct the process of committing endothelial cells to become arteries or veins during embryonic development.
High-Resolution Mapping Technique Uncovers Underlying Circuit Architecture of the Brain
June 27, 2013 Using an innovative brain-tracing technique, scientists have found a way to untangle the complex connections that influence specific brain functions.
Scientists Discover DNA Damage Occurs as Part of Normal Brain Activity
April 01, 2013Scientists at the UCSF-affiliated Gladstone Institutes have discovered that a certain type of DNA damage long thought to be particularly detrimental to brain cells can actually be part of a regular, non-harmful process.
Scientists Identify Infection Strategy of Widespread Virus
December 20, 2012Scientists at the Gladstone Institutes have mapped the molecular mechanism by which a virus known as cytomegalovirus (CMV) so successfully infects its hosts. This discovery paves the way for new research avenues aimed at fighting this and other seemingly benign viruses that can turn deadly.
Gladstone Scientists Recommend Renewed Focus on ApoE as Target for Halting Alzheimer's Disease
December 06, 2012Scientists at the Gladstone Institutes, which is affiliated with UCSF, are recommending a shift in efforts to treat Alzheimer’s disease by developing drugs that target the apoE4 protein, which has long been associated with an increased risk for the disease.
Scientists Identify Key Biological Mechanism in Multiple Sclerosis
November 30, 2012Scientists at the UCSF-affiliated Gladstone Institutes have defined for the first time a key underlying process implicated in multiple sclerosis — a discovery offers new hope for the millions who suffer from this debilitating disease for which there is no cure.
Scientists Collaborate to Block Toxic Protein that Plays Key Role in Lou Gehrig's Disease
October 29, 2012Scientists at the UCSF-affiliated Gladstone Institutes and the Stanford University School of Medicine have discovered how modifying a gene halts the toxic buildup of a protein found in nerve cells. These findings point to a potential new tactic for treating a variety of neurodegenerative conditions, including amyotrophic lateral sclerosis (ALS, or Lou Gehrig’s disease).
Gladstone President to Receive Prestigious Pacesetter Award
October 29, 2012Gladstone President R. Sanders "Sandy" Williams, MD, a professor of medicine at UCSF, will receive the ARCS Foundation’s 2012 Pacesetter Award next week for his lifelong dedication to furthering education and his extensive contributions to science and medicine.
Protein Deficiency in Brain Plays Key Role in Early-Onset Dementia
October 09, 2012Scientists at the UCSF-affiliated Gladstone Institutes have discovered how a protein deficiency may be linked to frontotemporal dementia (FTD) — a form of early-onset dementia similar to Alzheimer’s disease. These results lay the foundation for therapies that one day may benefit those who suffer from this and related brain diseases.
Researchers Map Gene 'Bursting' in Protein Production
October 09, 2012Scientists at the UCSF-affiliated Gladstone Institutes have mapped the precise frequency by which genes get turned on across the human genome, providing new insight into the most fundamental of cellular processes — and revealing new clues as to what happens when this process goes awry.
