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COVID Patients on SSRI Antidepressants Are Less Likely to Die, UCSF-Stanford Study Finds
A UCSF and Stanford study of electronic health records linked SSRIs, the most widely prescribed antidepressants, to survival for COVID-19 patients.
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UCSF Rises in US News Global Universities Rankings for 2022
UCSF’s research has been ranked among the top in the world, according to the latest U.S. News & World Report’s Best Global Universities 2022 rankings.
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How Cells Multitask: The Magic of Molecular Switches
Researchers at UCSF’s Quantitative Biosciences Institute (QBI) have observed how molecular switches regulate many different biological processes simultaneously. Their findings may shed light on how disease mutations operate, offering new ways to target malfunctioning switches and prevent illness.
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Scientists Map Brain Circuit that Drives Activity in Fertile Females
A team of UCSF scientists have identified the specific neurons and signaling pathway that make sexually receptive females of many species more active at the time of ovulation.
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UCSF and Northwestern Awarded $4.2M to Advance Glioblastoma Therapeutics
Glioblastoma is the most common malignant brain tumor and among the most treatment-resistant cancers. In the last 15 years, numerous attempts to develop new drugs for glioblastoma have failed.
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This Molecule Could Be the Key to Understanding Why Concussions Have Such Long-Term Effects
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Data-Driven Drug Dosing Speeds Tuberculosis Treatment to 4 Months
A clinical trial of new treatment regimens, led in part by researchers at UCSF, recently demonstrated that a more potent combination of antibiotics could shorten the duration of treatment for TB.
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Here’s Why Poisonous Animals Don’t Poison Themselves
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Poison Frogs, Birds, Hold Clues to Antidotes for Deadly Toxins
A team of researchers at have uncovered some intriguing clues in the mystery of how some poison birds and frogs evade their own toxins.
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Dual-Drug Therapy Shows Promise for Treating Alcohol Use Disorder
UCSF researchers have leveraged two new molecules, one of which is currently in clinical oncology trials, to devise a dual-drug therapy for alcohol use disorder (AUD), without the side effects or complications associated with current treatment regimens.
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UCSF Co-led Study Demonstrates Safety and Efficacy of 4-Month Tuberculosis Treatment Regimen
UCSF researchers in collaboration with the Centers for Disease Control’s Tuberculosis Trials Consortium and the AIDS Clinical Trials Group published a landmark study that demonstrated a new four-month treatment regimen for tuberculosis was safe and as efficacious as the standard six-month therapy.
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Common COVID-19 Antibiotic No More Effective Than Placebo
A UCSF study has found that the antibiotic azithromycin was no more effective than a placebo in preventing symptoms of COVID-19 among non-hospitalized patients, and may increase their chance of hospitalization, despite widespread prescription of the antibiotic for the disease.
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The Reassuring Data on the Delta Variant
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Beyond CAR-T: New Frontiers in Living Cell Therapies
Taking a page from computer engineers, biologists are trying their hands at programming cells – by building DNA circuits to guide their protein-making machinery and behavior.
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Microbiome Medicine: Scientists Harness the Body’s ‘Bugs’ to Treat Asthma, MS and More
Plenty of probiotic yogurts, pickles and kombuchas claim to boost our digestive health with armies of microbes, but some scientists have more ambitious therapeutic plans for the “bugs” that colonize us. They hope to leverage these microbes as living therapeutics for a range of health conditions, including ulcerative colitis, multiple sclerosis, eczema and asthma.
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Next-Generation T-Cell Therapeutics Set Sights on Cancers, Autoimmune Disorders and More
T cells – immune cells that patrol our bodies in search of trouble – have become a central focus for UC San Francisco scientists working on living cell therapies, an approach that views cells
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Mutation in Highly Infectious Alpha Variant May Help Coronavirus Evade Immune System
The B.1.1.7 coronavirus variant—also known as Alpha—may be more infectious because it contains mutations that make it better adapted to foil the innate immune system, at least for long enough to allow the virus to replicate and potentially find new hosts, according to a new study.
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The Case of the Recurring Fever
An elderly man had symptoms no one could explain – until Amy Berger, MD, PhD, and her team investigated.
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Your Immune System Could Turn COVID-19 Deadly
Hidden autoimmunity may explain how the coronavirus wreaks such widespread and unpredictable harm.
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TED Talk: “Can We Create Vaccines that Mutate and Spread?”
The viruses that cause polio and COVID-19 mutate, but treatments for the diseases don’t. For over 20 years, UCSF and Gladstone Institutes scientist Leor Weinberger, PhD, has been thinking of ways to make vaccines work more efficiently by being adaptive, rather than static.
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Space Travel Weakens Our Immune Systems – Now Scientists May Know Why
Scientists now have shown that the weakening of an astronaut’s immune system during space travel is likely due in part to abnormal activation of immune cells called T regulator cells.
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Sophie Dumont Delivers 2021 Byers Award Lecture: ‘Who Conducts the Symphony of Cell Division?’
Sophie Dumont, winner of the 2021 Byers Award for Basic Science, focuses on finding out how, as well whether therapeutic targets exist to ensure equal – and healthy – division of chromosomes.
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Novel Structure Found in Tumor Cells May Open Door to New Kinds of Cancer Therapies
UCSF researchers have figured out precisely what receptor tyrosine kinases are, how they form and their role in cancer.
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Smart Cell Therapies for Solid Cancers Ready to Move Toward Clinical Trials
Researchers at UCSF have demonstrated how to engineer smart immune cells that are effective against solid tumors, opening the door to treating a variety of cancers that have long been untouchable with immunotherapies.
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New Technique Maps Cell Locations, Hinting at Their Roles
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New CRISPR Technology Offers Unrivaled Control of Epigenetic Inheritance
Scientists have figured out how to modify CRISPR’s basic architecture to extend its reach beyond the genome and into what’s known as the epigenome.
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Pancreatic Cancer Cells Hijack Muscle Protein to Beef Up Their Metabolism
Cancer starts with mutations in a cell’s DNA, but new UCSF research shows that the endurance of a tumor relies on its ability to rapidly evolve and adapt to challenges brought about by the environment in which it grows.
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Key Decision Point for Brain Development Identified
In a new study, UCSF and Stanford researchers have identified a central switch that appears to control when neural progenitor cells stop multiplying and start differentiating into mature neurons.
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Store Fat or Burn It? Targeting a Single Protein Flips the Switch
UCSF researchers found that mice in which activity of a protein called eIF4E is diminished, either genetically or pharmaceutically, gain only half the weight of other mice, even if all the mice eat a high-fat diet.
