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UC San Francisco researchers have finally identified the cellular circuit responsible for conveying stress signals from inside mitochondria to the integrated stress response, a discovery that may have important implications for treating the many debilitating diseases associated with mitochondrial stress.
A simple blood test may soon be able to diagnose patients with two common forms of dementia – Alzheimer’s disease and frontotemporal dementia – and tell the two apart.
The study also identified 12 other FDA-approved drugs that are deemed safe in pregnancy.
Researchers screened a massive library of over 150 million virtual molecules and discovered the first drugs that selectively target one of two mammalian melatonin receptors that modulate sleep-wake cycles.
Researchers found that when default settings, showing a preset number of opioid pills, were modified downward, physicians prescribed fewer pills. Fewer pills could improve prescription practices and protect patients from developing opioid addictions.
UCSF–led research team has discovered the first conclusive evidence that natural selection may also occur at the level of the epigenome and has done so for tens of millions of years.
The breakthroughs came as Jack Levin was trying to find out if the cells normally circulating in the horseshoe crab’s blood, called amebocytes, triggered clotting, as platelets do in human blood.
A survey found that fewer than half of California pharmacies provided antibiotics and opioids disposal instructions meeting U.S. FDA guidelines, and just 10 percent followed the FDA’s preferred recommendation to take back unused medications from their customers.
A drug that once helped obese adults lose weight, but was withdrawn from the market due to heart risks, may be safe and effective for children with a life-threatening seizure disorder called Dravet syndrome.
After phages infect bacteria, they construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses.
Research shows that after cells are subjected to certain stressful treatments, they appear to gain a new “superpower” that allows them to grow twice as fast as normal — a feature the authors call “supergrowth.”
Using standard animal model of Down syndrome, scientists were able to correct the learning and memory deficits associated with the condition with drugs that target the body’s response to cellular stresses.
In a breakthrough with important implications for the future of immunotherapy for breast cancer, UCSF scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.
The net clinical benefit of anticoagulants for atrial fibrillation decreases with age.
Now in its sixth year, the Best Global Universities rankings focus on schools’ academic research and reputation.
Research team has detected the immunological remnants of a common seasonal virus in spinal fluid from dozens of patients diagnosed with acute flaccid myelitis (AFM). The findings provide the clearest evidence to date that AFM is caused by an enterovirus (EV) that invades and impairs the central nervous system.
The UCSF scientists who identified the two known human genes that promote “natural short sleep” have now discovered a third, and it’s also the first gene that’s ever been shown to prevent the memory deficits that normally accompany sleep deprivation.
International team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease, a rare genetic condition affecting boys that can be fatal before 10 years of age.
Julius received the prize “for discovering molecules, cells, and mechanisms underlying pain sensation.”
Researchers discovered a scorpion toxin that targets the “wasabi receptor,” which they think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.
Study shows that the adult-to-iPSC conversion process can mutate DNA found in mitochondria, causing mice and humans to reject iPSCs, and stem cell transplants more generally.
In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.