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Displaying 31 - 60 of 297
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Cellular SOS: CRISPR Technique Reveals How Cell’s ‘Power Plants’ Activate Emergency Response
UC San Francisco researchers have finally identified the cellular circuit responsible for conveying stress signals from inside mitochondria to the integrated stress response, a discovery that may have important implications for treating the many debilitating diseases associated with mitochondrial stress.
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Simple Blood Test May be Able to Diagnose Alzheimer’s Disease
A simple blood test may soon be able to diagnose patients with two common forms of dementia – Alzheimer’s disease and frontotemporal dementia – and tell the two apart.
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Acid Reflux Drug Is a Surprising Candidate to Curb Preterm Birth
The study also identified 12 other FDA-approved drugs that are deemed safe in pregnancy.
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‘Virtual Pharmacology’ Yields Unprecedented Biological Clock Breakthrough
Researchers screened a massive library of over 150 million virtual molecules and discovered the first drugs that selectively target one of two mammalian melatonin receptors that modulate sleep-wake cycles.
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There's So Much We Still Don't Know About Pain
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The simple design change that could help doctors prevent opioid addiction
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Opioid Prescriptions Affected by Computer Settings
Researchers found that when default settings, showing a preset number of opioid pills, were modified downward, physicians prescribed fewer pills. Fewer pills could improve prescription practices and protect patients from developing opioid addictions.
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‘Living Fossil’ May Upend Basic Tenet of Evolutionary Theory
UCSF–led research team has discovered the first conclusive evidence that natural selection may also occur at the level of the epigenome and has done so for tens of millions of years.
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How a Study of Horseshoe Crabs Led to Safer Joint Replacements
The breakthroughs came as Jack Levin was trying to find out if the cells normally circulating in the horseshoe crab’s blood, called amebocytes, triggered clotting, as platelets do in human blood.
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Pharmacies Leave Customers Hanging When It Comes to Disposing of Antibiotics and Opioids
A survey found that fewer than half of California pharmacies provided antibiotics and opioids disposal instructions meeting U.S. FDA guidelines, and just 10 percent followed the FDA’s preferred recommendation to take back unused medications from their customers.
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Old Drug Offers New Hope for Children with Devastating Disorder
A drug that once helped obese adults lose weight, but was withdrawn from the market due to heart risks, may be safe and effective for children with a life-threatening seizure disorder called Dravet syndrome.
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The Startling Secret of an Invincible Virus
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CRISPR-Resistant Viruses Build ‘Safe Rooms’ to Shield Genomes from DNA-Dicing Enzymes
After phages infect bacteria, they construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses.
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‘Supergrowth’ Challenges Established Science of Cell Growth
Research shows that after cells are subjected to certain stressful treatments, they appear to gain a new “superpower” that allows them to grow twice as fast as normal — a feature the authors call “supergrowth.”
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In Down Syndrome Mouse Model, Scientists Reverse Intellectual Deficits with Drugs
Using standard animal model of Down syndrome, scientists were able to correct the learning and memory deficits associated with the condition with drugs that target the body’s response to cellular stresses.
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Researchers Halt Spread of Breast Cancer by Blocking Metastasis-Promoting Enzyme
In a breakthrough with important implications for the future of immunotherapy for breast cancer, UCSF scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.
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Anticoagulant Benefits for Atrial Fibrillation Decrease With Age
The net clinical benefit of anticoagulants for atrial fibrillation decreases with age.
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Breakthrough Prize, The ‘Oscars Of Science,’ Pairs Hollywood Stars With Silicon Valley Elite
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UCSF Tops US News Global University Rankings in 9 Research Areas
Now in its sixth year, the Best Global Universities rankings focus on schools’ academic research and reputation.
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UCSF finds major clue to the cause of sudden-onset paralysis in children
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‘Missing’ Virus Detected in Dozens of Children Paralyzed by Polio-Like Illness
Research team has detected the immunological remnants of a common seasonal virus in spinal fluid from dozens of patients diagnosed with acute flaccid myelitis (AFM). The findings provide the clearest evidence to date that AFM is caused by an enterovirus (EV) that invades and impairs the central nervous system.
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Virtual Reality View of Mutations Can Reveal Better Ways to Treat Cancer
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‘Short Sleep’ Gene Prevents Memory Deficits Associated with Sleep Deprivation
The UCSF scientists who identified the two known human genes that promote “natural short sleep” have now discovered a third, and it’s also the first gene that’s ever been shown to prevent the memory deficits that normally accompany sleep deprivation.
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Stem Cell Studies Offer Hope for Childhood Neurological Condition
International team of researchers report progress in using stem cells to develop new therapies for Pelizaeus-Merzbacher disease, a rare genetic condition affecting boys that can be fatal before 10 years of age.
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David Julius Receives $3M Breakthrough Prize for Work on Pain Sensation
Julius received the prize “for discovering molecules, cells, and mechanisms underlying pain sensation.”
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Scorpion Toxin That Targets ‘Wasabi Receptor’ May Help Solve Mystery of Chronic Pain
Researchers discovered a scorpion toxin that targets the “wasabi receptor,” which they think it can be used as a tool for studying chronic pain and inflammation, and may eventually lead to the development of new kinds of non-opioid pain relievers.
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New Clues on Stem Cell Transplant Rejection Revealed in Study
Study shows that the adult-to-iPSC conversion process can mutate DNA found in mitochondria, causing mice and humans to reject iPSCs, and stem cell transplants more generally.
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Tweaked CRISPR in Neurons Gives Scientists New Power to Probe Brain Diseases
In a paper researchers describe a technique that uses a special version of CRISPR developed at UCSF to systematically alter the activity of genes in human neurons generated from stem cells, the first successful merger of stem cell-derived cell types and CRISPR screening technologies.
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Scientists Can Finally Build Feedback Circuits in Cells
