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Rethinking How Cancer Cells Evade Targeted Therapy

Through decades of biobanking at UCSF, researchers were able to comprehensively map intra-cellular signaling in the cells of recurrent glioblastoma, identifying novel cell-extrinsic therapeutic targets.

microscope image of green glioblastoma cells and blue brain organoids

More than 30 Researchers Among Most Influential

38 UCSF researchers rank in the top 1 percent for impact in their fields, according to a new analysis of research citations by science and intellectual property company Clarivate.

A female Hispanic researcher wearing a lab coat works in a laboratory

Down Syndrome, Like Alzheimer’s, Is a Double-Prion Disorder

The brains of people with Down syndrome develop the same neurodegenerative tangles and plaques associated with Alzheimer’s disease and frequently demonstrate signs of the neurodegenerative disorder in their forties or fifties. A new study shows that these tangles and plaques are driven by the same amyloid beta (Aß) and tau prions as Alzheimer’s disease.

Microscopy of blue cells with clumps of yellow proteins, indicating contact with prion forms of amyloid beta