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The First Genome Surgeons

The ascendancy of CRISPR systems raises a grand hope: If these tools can illuminate the causes of disease in the laboratory, why not bring them into the clinic to treat patients?

Portrait of Theo Roth, MD-PhD, in blue surgeon scrubs in front of an orange background; over his right shoulder is an illustrated double helix DNA strand with a little black oval shaped cartoon in a surgeon cap and mask holding scissors, hanging from the double helix.

Alexander R. Margulis, Visionary Chair of Radiology, Dies at 97

He was the heart of UCSF Radiology for the 26 years of his chairmanship, from 1963 to 1989, and led the extraordinary evolution of imaging that began with the early days of CT, MRI, US, PET-CT, interventional radiology, molecular imaging and other modalities.

CryoEM Study Captures Opioid Signaling in the Act

Scientists have used ultra-high-resolution cryo–electron microscopy to capture the most detailed portrait ever of an opioid drug triggering the biochemical signaling cascade that gives it its power.

Memory-Enhancing Drug Acts as Molecular 'Staple'

UCSF researchers have shown that an experimental brain boosting drug, ISRIB, acts like a molecular staple, pinning together parts of a much larger protein involved in cellular stress.