Though many hopes are hanging on the development of a vaccine or drug that targets the novel coronavirus directly, a UCSF-led team is taking an unconventional approach: target the host – in other words, you.
UC San Francisco researchers have finally identified the cellular circuit responsible for conveying stress signals from inside mitochondria to the integrated stress response, a discovery that may have important implications for treating the many debilitating diseases associated with mitochondrial stress.
Researchers screened a massive library of over 150 million virtual molecules and discovered the first drugs that selectively target one of two mammalian melatonin receptors that modulate sleep-wake cycles.
After phages infect bacteria, they construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses.
Research shows that after cells are subjected to certain stressful treatments, they appear to gain a new “superpower” that allows them to grow twice as fast as normal — a feature the authors call “supergrowth.”
Using standard animal model of Down syndrome, scientists were able to correct the learning and memory deficits associated with the condition with drugs that target the body’s response to cellular stresses.
In a breakthrough with important implications for the future of immunotherapy for breast cancer, UCSF scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.