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Down Syndrome, Like Alzheimer’s, Is a Double-Prion Disorder

The brains of people with Down syndrome develop the same neurodegenerative tangles and plaques associated with Alzheimer’s disease and frequently demonstrate signs of the neurodegenerative disorder in their forties or fifties. A new study shows that these tangles and plaques are driven by the same amyloid beta (Aß) and tau prions as Alzheimer’s disease.

Microscopy of blue cells with clumps of yellow proteins, indicating contact with prion forms of amyloid beta

$147M Grant Will Address Imbalances in Alzheimer’s Study

A $147 million grant will expand diversity among Alzheimer’s disease research participants, and involve partners from UCSF, the San Francisco VA Medical Center, and the Northern California Institute for Research and Education.

An MRI technician looks at brain scans in the foreground, while a subject is inside an MRI

Senescent Cells also Help to Heal Damaged Tissues

Not all senescent cells are harmful “zombies” that should be wiped out to prevent age-related disease. New research from UCSF found that some of them are embedded in young, healthy tissues and promote normal repair from damage.

A group of senescent cells are ligt up in flurescent fuscia and blue