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Researchers screened a massive library of over 150 million virtual molecules and discovered the first drugs that selectively target one of two mammalian melatonin receptors that modulate sleep-wake cycles.
Researchers found that when default settings, showing a preset number of opioid pills, were modified downward, physicians prescribed fewer pills. Fewer pills could improve prescription practices and protect patients from developing opioid addictions.
UCSF–led research team has discovered the first conclusive evidence that natural selection may also occur at the level of the epigenome and has done so for tens of millions of years.
The breakthroughs came as Jack Levin was trying to find out if the cells normally circulating in the horseshoe crab’s blood, called amebocytes, triggered clotting, as platelets do in human blood.
A survey found that fewer than half of California pharmacies provided antibiotics and opioids disposal instructions meeting U.S. FDA guidelines, and just 10 percent followed the FDA’s preferred recommendation to take back unused medications from their customers.
A drug that once helped obese adults lose weight, but was withdrawn from the market due to heart risks, may be safe and effective for children with a life-threatening seizure disorder called Dravet syndrome.
After phages infect bacteria, they construct an impenetrable “safe room” inside of their host, which protects vulnerable phage DNA from antiviral enzymes. This compartment, which resembles a cell nucleus, is the most effective CRISPR shield ever discovered in viruses.
Research shows that after cells are subjected to certain stressful treatments, they appear to gain a new “superpower” that allows them to grow twice as fast as normal — a feature the authors call “supergrowth.”
Using standard animal model of Down syndrome, scientists were able to correct the learning and memory deficits associated with the condition with drugs that target the body’s response to cellular stresses.
In a breakthrough with important implications for the future of immunotherapy for breast cancer, UCSF scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.
The net clinical benefit of anticoagulants for atrial fibrillation decreases with age.
